{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CDC42BPB encodes MRCKβ, a serine/threonine kinase that functions as a downstream effector of the small GTPase CDC42 to regulate cytoskeletal dynamics and cell polarity. In ErbB2‐positive breast cancer, CDC42BPB is an essential mediator in a signaling network that promotes cell invasiveness through the induction of cysteine cathepsin expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In kidney collecting duct cells, CDC42BPB is one of several kinases implicated in modulating F‐actin reorganization, a process critical for vesicle trafficking and water permeability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Proteomic profiling in ovarian cancer further revealed that CDC42BPB is overexpressed in cisplatin‐resistant cells, suggesting a role in chemotherapy response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Epigenome‐wide association studies have also identified altered methylation of CDC42BPB linked to depressive symptoms, thereby implicating the gene in neuropsychiatric conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, rare de novo variants in CDC42BPB have been associated with neurodevelopmental disorders, including features of Takenouchi‐Kosaki syndrome"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and a homozygous variant in CDC42BPB has been proposed to contribute to Müllerian duct anomalies in affected families."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " A genome‐wide association study in diffuse large B‐cell lymphoma identified a susceptibility locus within an intronic region of CDC42BPB, underscoring its potential relevance in hematological malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, chemical proteomic analyses have detected CDC42BPB as a novel kinase target of clinical inhibitors, highlighting its promise as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, analysis of urinary mRNA panels for bladder cancer risk stratification has incorporated CDC42BPB as a biomarker candidate."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings position CDC42BPB as a multifunctional regulator at the intersection of cytoskeletal remodeling, cell invasion, developmental processes, and disease pathogenesis, with emerging potential as both a biomarker and therapeutic target across diverse biological contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bo Rafn, Christian Friberg Nielsen, Sofie Hagel Andersen, et al. 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