{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cell division cycle associated 3 (CDCA3) is emerging as a central regulator of cell cycle progression that functions as a trigger for mitotic entry by mediating the timely degradation of inhibitory kinases such as Wee1. In various tumor types, aberrant overexpression of CDCA3 disrupts normal cell cycle checkpoints and promotes oncogenic processes by facilitating G1/S and G2/M transitions, thereby enhancing cellular proliferation, migration, invasion, and even resistance to targeted therapies. For instance, in oral squamous cell carcinoma, increased CDCA3 levels accelerate cell cycle progression via reduced expression of cyclin‐dependent kinase inhibitors, whereas in colorectal cancer, elevated CDCA3 either by transcriptional upregulation or loss of regulatory microRNAs (like miR‐145‐5p) leads to diminished p21 accumulation and enhanced E2F1 activity, propelling malignant growth and NF‑κB activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In renal cell carcinoma, a long noncoding RNA (SNHG12) enhances CDCA3 expression via stabilization of the SP1 transcription factor, thereby promoting tumor progression and sunitinib resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in prostate cancer, CDCA3 is upregulated as a downstream target of HoxB3, contributing to increased proliferation and tumor aggressiveness"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and further validated by studies showing that its knockdown reduces NF‑κB signaling and impairs cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in lung cancer, CDCA3 is part of a regulatory axis involving circRNA and microRNAs that modulates key cellular processes including glycolysis alongside proliferation and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while in acute myeloid leukemia, a miR‐375–HOXB3–CDCA3/DNMT3B circuitry underscores its role in leukemic cell survival and proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, large‐scale gene expression profiling studies have identified CDCA3 as a novel oncogene whose overexpression correlates with aggressive tumor behavior across multiple malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these findings highlight the prognostic and therapeutic potential of targeting CDCA3 in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fumihiko Uchida, Katsuhiro Uzawa, Atsushi Kasamatsu, et al. 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