CDCA7 Gene

Name	cell division cycle associated 7
Description	This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CDCA7 is a multifaceted protein that integrates signals from several key transcriptional regulators to modulate cell cycle progression, apoptosis, and genomic stability. It is transcriptionally induced by oncogenic factors such as MYC and E2F1, and its activity is further modulated by AKT‐dependent phosphorylation, which regulates its subcellular localization and its ability to potentiate MYC‐dependent apoptosis and transformation in neoplastic cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, CDCA7 is a direct Notch target that becomes enriched in hematopoietic clusters, where it helps sustain the undifferentiated state of progenitor cells and is essential for proper hematopoietic stem cell emergence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In several human cancers—including triple‐negative breast, colorectal, ovarian, and lung adenocarcinomas—CDCA7 is frequently overexpressed. Its elevated levels correlate with increased tumor aggressiveness, metastasis, and poorer patient outcomes; for example, in triple‐negative breast cancer CDCA7 enhances the transcription of EZH2, a key promoter of tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in tumorigenesis, mutations in CDCA7 have been identified in patients with Immunodeficiency, Centromeric Instability, and Facial anomalies (ICF) syndrome. These mutations not only underscore its importance in maintaining pericentromeric methylation and chromatin stability but also link CDCA7 to a protein complex (the CDCA7/HELLS complex) that facilitates classical nonhomologous end joining and proper DNA repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Transcriptional regulation of CDCA7 is further refined by factors such as ZBTB24, which directly occupies its promoter and governs its expression in both murine and human systems"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", reinforcing the convergence of regulatory pathways that ensure proper cell proliferation and genome maintenance.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings indicate that CDCA7 serves as a critical effector that links oncogenic signaling pathways (MYC, E2F, and Notch) with the cellular machinery responsible for genome stability and cell fate decisions. Its dysregulation—either through overexpression in various malignancies or mutation in developmental syndromes such as ICF—contributes to aberrant cell proliferation, impaired DNA repair, and tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "R Montgomery Gill, Timothy V Gabor, Amber L Couzens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00276-12"}], "href": "https://doi.org/10.1128/MCB.00276-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23166294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23166294"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuya Goto, Reiko Hayashi, Tomoki Muramatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbaexp.2006.02.004"}], "href": "https://doi.org/10.1016/j.bbaexp.2006.02.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16580749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16580749"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jordi Guiu, Dylan J M Bergen, Emma De Pater, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20131857"}], "href": "https://doi.org/10.1084/jem.20131857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25385755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25385755"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Emman Shubbar, Anikó Kovács, Shahin Hajizadeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-1"}], "href": "https://doi.org/10.1186/1471-2407-13-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23282137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23282137"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Liping Ye, Fengyan Li, Yipeng Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of CDCA7 predicts poor prognosis and induces EZH2-mediated progression of triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31766"}], "href": "https://doi.org/10.1002/ijc.31766"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30151890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30151890"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Siman Li, Jiean Huang, Mengbin Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11089"}], "href": "https://doi.org/10.3892/mmr.2020.11089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32319649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32319649"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chunyan Cai, Xing Peng, Yumei Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1965441"}], "href": "https://doi.org/10.1080/21655979.2021.1965441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34551671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34551671"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Swanand Hardikar, Zhengzhou Ying, Yang Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13238-019-00682-w"}], "href": "https://doi.org/10.1007/s13238-019-00682-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31970665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31970665"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Peter E Thijssen, Yuya Ito, Giacomo Grillo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8870"}], "href": "https://doi.org/10.1038/ncomms8870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26216346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26216346"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Motoko Unoki, Jafar Sharif, Yuichiro Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-74636-2"}], "href": "https://doi.org/10.1038/s41598-020-74636-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33082427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33082427"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Haoyu Wu, Peter E Thijssen, Eleonora de Klerk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddw243"}], "href": "https://doi.org/10.1093/hmg/ddw243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27466202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27466202"}]}]}]}
Synonyms	JPO1, ICF3
Proteins	CDCA7_HUMAN
NCBI Gene ID	83879
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CDCA7 has 6,165 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for CDCA7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CDCA7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDCA7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDCA7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CDCA7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CDCA7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CDCA7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDCA7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDCA7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDCA7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDCA7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CDCA7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CDCA7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CDCA7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDCA7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CDCA7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CDCA7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CDCA7 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CDCA7 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CDCA7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CDCA7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CDCA7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CDCA7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CDCA7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDCA7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CDCA7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CDCA7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CDCA7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CDCA7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CDCA7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CDCA7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CDCA7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CDCA7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CDCA7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CDCA7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CDCA7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CDCA7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDCA7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CDCA7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CDCA7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CDCA7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CDCA7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.