{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cadherin‐7 (CDH7) is a calcium‐dependent cell–cell adhesion glycoprotein that plays multifaceted roles in both development and disease. In the developing and adult central nervous system, CDH7 is expressed in discrete neuronal populations and neural crest derivatives, where it helps to establish layer‐specific organization and mediates the adhesion and sorting of neurites that is critical for proper circuit formation (see"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In the chick model, for example, tightly regulated CDH7 expression in neural crest cells is required for their proper emigration and migration, ensuring correct assembly of cranial ganglia and accurate targeting of pigment precursors (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, studies investigating tissue mechanics have demonstrated that specific extracellular domains of CDH7 modulate intercellular adhesion forces, thereby influencing epithelial integrity, tensile strength, and collective cell migration (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Aberrant expression or mutation of CDH7 has been associated with a range of pathologic conditions. In cancer, CDH7 mutations have been identified in pulmonary sarcomatoid carcinoma (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "and are proposed as candidate events in central nervous system metastasis in neuroblastoma (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In malignant melanoma, CDH7 interacts with melanoma inhibitory activity (MIA), and its dysregulation alters cell migration and adhesion, thereby affecting tumor progression (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In addition, human genetic studies have implicated CDH7 variants as risk factors for major depressive disorder, suggesting that subtle alterations in cell adhesion may contribute to neuropsychiatric dysfunction (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, expression analyses in avian models have further shown that CDH7 marks discrete cell clusters within the striatum, implying an evolutionarily conserved role in the segregation and patterning of neuronal assemblies (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings indicate that CDH7 orchestrates dynamic, context‐dependent adhesive interactions that are crucial for proper neural development, circuit assembly, and tissue integrity, while its dysregulation is linked to diverse pathologies including cancer and mood disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Robert Moore, Delphine Champeval, Laurence Denat, et al. 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