CDK11A Gene

HGNC Family	Cyclin-dependent kinases (CDK)
Name	cyclin-dependent kinase 11A
Description	This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CDK11A is a multifaceted cyclin‐dependent kinase that is expressed as distinct isoforms through internal ribosome entry site–dependent translation. The full‐length CDK11(p110) is constitutively produced and participates in transcriptional regulation and RNA processing, whereas the shorter CDK11(p58) is selectively translated during the G2/M phase and localizes to centrosomes. CDK11(p58) plays a critical role in mitotic progression by ensuring proper centrosome maturation, spindle formation, and sister chromatid cohesion, in addition to regulating centriole duplication. These mitotic activities appear to be tightly coupled with a switch in translational mechanisms—from cap‐dependent to internal ribosome entry site–dependent translation—that is necessary for the accurate expression of key mitotic regulators, including its own IRES‐dependent isoform. Loss or inadequate expression of CDK11A, as revealed by RNA interference studies, results in impaired spindle assembly, defective cytokinesis, abnormal centrosome numbers, and genomic instability, all of which have been linked to tumorigenesis. Moreover, CDK11A interacts with other cell cycle regulators such as cyclin D3 to enhance its kinase activity during mitosis. Collectively, these findings establish CDK11A as an essential coordinator of mitotic events whose dysregulation may contribute to a variety of cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maria Barna, Aya Pusic, Ornella Zollo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature07449"}], "href": "https://doi.org/10.1038/nature07449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19011615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19011615"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Erik W Wilker, Marcel A T M van Vugt, Steven A Artim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3sigma controls mitotic translation to facilitate cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature05584"}], "href": "https://doi.org/10.1038/nature05584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17361185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17361185"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Clotilde Petretti, Matthew Savoian, Emilie Montembault, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7400639"}], "href": "https://doi.org/10.1038/sj.embor.7400639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16462731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16462731"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sandrine A Tinton, Bert Schepens, Yanik Bruynooghe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20040963"}], "href": "https://doi.org/10.1042/BJ20040963"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15330758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15330758"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dongli Hu, Marcus Valentine, Vincent J Kidd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK11(p58) is required for the maintenance of sister chromatid cohesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.007963"}], "href": "https://doi.org/10.1242/jcs.007963"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17606997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17606997"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Songwen Zhang, Mingmei Cai, Si Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M202179200"}], "href": "https://doi.org/10.1074/jbc.M202179200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12082095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12082095"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nathalie Franck, Emilie Montembault, Pierre Romé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0014600"}], "href": "https://doi.org/10.1371/journal.pone.0014600"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21297952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21297952"}]}]}]}
Synonyms	CDC2L3, CDC2L2, P58GTA, PITSLRE
Proteins	CD11A_HUMAN
NCBI Gene ID	728642
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CDK11A has 5,902 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 111 datasets.

Click the + buttons to view associations for CDK11A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CDK11A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK11A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK11A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CDK11A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CDK11A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CDK11A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK11A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CDK11A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDK11A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CDK11A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDK11A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with CDK11A gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CDK11A protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDK11A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CDK11A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CDK11A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CDK11A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CDK11A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CDK11A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CDK11A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CDK11A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CDK11A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDK11A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CDK11A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CDK11A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CDK11A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CDK11A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CDK11A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CDK11A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDK11A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CDK11A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GAD Gene-Disease Associations	diseases associated with CDK11A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CDK11A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CDK11A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CDK11A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CDK11A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CDK11A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of CDK11A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of CDK11A gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CDK11A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of CDK11A gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.