CDK5RAP3 Gene

Name	CDK5 regulatory subunit associated protein 3
Description	This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CDK5RAP3 (also known as C53 or LZAP) is a multifunctional regulatory protein that modulates diverse intracellular signaling pathways and cellular processes. It functions as a component of the UFM1 conjugation system, where its interaction with UFM1‐binding partners helps to maintain endoplasmic reticulum (ER) homeostasis and protect secretory cells from ER stress–induced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, CDK5RAP3 plays a critical role in cell cycle regulation and the DNA damage response. It modulates the G2/M checkpoint by promoting Cdk1–cyclin B1 activation and facilitating timely mitotic entry, thus affecting cellular sensitivity to genotoxic stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer, CDK5RAP3 exhibits context‐dependent functions. In hepatocellular carcinoma, its overexpression is associated with enhanced metastatic potential via binding to and activating PAK4 as well as repressing p14(ARF) transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " By contrast, in gastric and papillary thyroid carcinomas, reduced expression of CDK5RAP3 correlates with increased proliferation, invasion, and tumorigenicity. Here, CDK5RAP3 acts as a tumor suppressor by inhibiting key signaling pathways—specifically, by repressing AKT phosphorylation, which leads to decreased GSK‐3β phosphorylation and subsequent downregulation of β‐catenin activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, CDK5RAP3 is implicated in the regulation of apoptosis induced by genotoxic agents and in modulating checkpoint responses, in part by interacting with key cell cycle and transcription regulatory proteins such as DDRGK1, RCAD, and CBP."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": " Collectively, these studies highlight that CDK5RAP3 is a versatile modulator of cell proliferation, apoptosis, and differentiation whose dysregulation can impact tumor progression, metastasis, and tissue regeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Katleen Lemaire, Rodrigo F Moura, Mikaela Granvik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0018517"}], "href": "https://doi.org/10.1371/journal.pone.0018517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21494687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21494687"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hai Jiang, Shouqing Luo, Honglin Li "}, {"type": "b", "children": [{"type": "t", "text": "Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413431200"}], "href": "https://doi.org/10.1074/jbc.M413431200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15790566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15790566"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hai Jiang, Jianchun Wu, Chen He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2009.14"}], "href": "https://doi.org/10.1038/cr.2009.14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19223857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19223857"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Grace Wing-Yan Mak, Mandy Man-Lok Chan, Veronica Yee-Law Leong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-4046"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-4046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21385901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21385901"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Grace Wing-Yan Mak, Wai-Lung Lai, Yuan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0042210"}], "href": "https://doi.org/10.1371/journal.pone.0042210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22860085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22860085"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jia-Bin Wang, Zu-Wei Wang, Yun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.10.024"}], "href": "https://doi.org/10.1016/j.canlet.2016.10.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27793695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27793695"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chao-Hui Zheng, Jia-Bin Wang, Man-Qiang Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-0716-4"}], "href": "https://doi.org/10.1186/s13046-018-0716-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29540196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29540196"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiaolei Feng, Jue Jiang, Lei Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Appl Pharmacol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.taap.2022.115940"}], "href": "https://doi.org/10.1016/j.taap.2022.115940"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35219640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35219640"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v24.i34.3898"}], "href": "https://doi.org/10.3748/wjg.v24.i34.3898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30228783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30228783"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jianchun Wu, Guohua Lei, Mei Mei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.110619"}], "href": "https://doi.org/10.1074/jbc.M110.110619"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20228063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20228063"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jialiang Wang, Xiaping He, Ying Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20050960"}], "href": "https://doi.org/10.1042/BJ20050960"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16173922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16173922"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shuchun Yang, Rui Yang, Huanmin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2020.08.011"}], "href": "https://doi.org/10.1016/j.ajpath.2020.08.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32926856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32926856"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xiaolong Yin, Dennis R Warner, Emily A Roberts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16012757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16012757"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jialiang Wang, Hanbing An, Marty W Mayo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2007.07.002"}], "href": "https://doi.org/10.1016/j.ccr.2007.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17785205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17785205"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "D Stav, I Bar, J Sandbank "}, {"type": "b", "children": [{"type": "t", "text": "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Markers (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/172460080702200204"}], "href": "https://doi.org/10.1177/172460080702200204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17549666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17549666"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jun Li, Xinyi Hu, Ming Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/6171782"}], "href": "https://doi.org/10.1155/2019/6171782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31061682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31061682"}]}]}]}
Synonyms	MST016, PP1553, IC53, C53, HSF-27, LZAP, OK/SW-CL.114
Proteins	CK5P3_HUMAN
NCBI Gene ID	80279
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CDK5RAP3 has 7,032 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for CDK5RAP3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CDK5RAP3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK5RAP3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK5RAP3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CDK5RAP3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CDK5RAP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CDK5RAP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDK5RAP3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CDK5RAP3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDK5RAP3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDK5RAP3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CDK5RAP3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDK5RAP3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CDK5RAP3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CDK5RAP3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CDK5RAP3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDK5RAP3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CDK5RAP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CDK5RAP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CDK5RAP3 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CDK5RAP3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CDK5RAP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CDK5RAP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CDK5RAP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CDK5RAP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CDK5RAP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CDK5RAP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDK5RAP3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CDK5RAP3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CDK5RAP3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CDK5RAP3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CDK5RAP3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CDK5RAP3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CDK5RAP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CDK5RAP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CDK5RAP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CDK5RAP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CDK5RAP3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDK5RAP3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CDK5RAP3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CDK5RAP3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CDK5RAP3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.