CDKN2AIP Gene

Name	CDKN2A interacting protein
Description	The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CDKN2AIP (also known as CARF) is emerging as a multifaceted regulator of cell fate whose functions encompass the control of tumor‐suppressive and proliferative pathways. Initially identified as an ARF‐binding protein, CDKN2AIP potentiates p53 activation by interacting not only with ARF but also directly with p53 and its key negative regulator MDM2, thereby influencing cell cycle arrest, senescence, and the DNA damage response."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In addition, CDKN2AIP plays a role in maintaining genomic integrity by participating in checkpoint signaling and modulating pathways activated upon genotoxic or oxidative stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Its interaction with the RNA exoribonuclease XRN2 through a conserved binding domain suggests a further involvement in the regulation of rRNA processing and ribosome biogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its central role in the p53 network, dysregulation of CDKN2AIP has been linked to oncogenesis and disease progression in several cancer types. Candidate genetic variants and altered expression of CDKN2AIP have been associated with predisposition to esophageal squamous cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while proteomics studies in colorectal cancer metastasis highlight its potential as a biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Its altered expression is also observed in other clinical contexts such as lung cancer distant metastasis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "and in benign disorders, as exemplified by its downregulation in nevus sebaceous."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, CDKN2AIP appears to participate in other signaling networks: microRNA‐mediated regulation (via miR‑302c, miR‑335, and miR‑451) further modulates its levels and, consequently, p53 activity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "; its involvement in Wnt/β‑catenin signaling is evidenced by direct interactions with key pathway components, where small molecules (e.g. NC043) that target CDKN2AIP can disrupt these interactions and attenuate Wnt signal transduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Finally, genetic association studies have even identified CDKN2AIP as a candidate gene influencing reproductive traits in boars"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and its regulation via circular RNA networks has been implicated in osteosarcoma angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, the available evidence supports a pivotal role for CDKN2AIP/CARF as a modulator of both tumor suppressive mechanisms (through p53 stabilization, cell cycle checkpoint activation, and maintenance of genomic integrity) and oncogenic pathways (via regulation of Wnt and other signaling cascades). Alterations in its expression or function may not only influence cancer development and metastasis but also serve as a potential diagnostic or therapeutic target in diverse clinical settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Md Kamrul Hasan, Tomoko Yaguchi, Takashi Sugihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M204177200"}], "href": "https://doi.org/10.1074/jbc.M204177200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12154087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12154087"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kamrul Hasan, Caroline Cheung, Zeenia Kaul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CARF Is a vital dual regulator of cellular senescence and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M805778200"}], "href": "https://doi.org/10.1074/jbc.M805778200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19001376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19001376"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Caroline T Cheung, Rumani Singh, Rajkumar S Kalra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.547208"}], "href": "https://doi.org/10.1074/jbc.M114.547208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24825908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24825908"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rajkumar S Kalra, Caroline T Cheung, Anupama Chaudhary, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molonc.2015.07.003"}], "href": "https://doi.org/10.1016/j.molonc.2015.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26278998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26278998"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rumani Singh, Rajkumar S Kalra, Kamrul Hasan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2014.01.022"}], "href": "https://doi.org/10.1016/j.yexcr.2014.01.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24485912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24485912"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "C T Cheung, R Singh, A R Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of apoptosis induced by CARF silencing in human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2010.129"}], "href": "https://doi.org/10.1038/cdd.2010.129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21052095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21052095"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hannes Richter, Iskra Katic, Heinz Gut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis and function of XRN2 binding by XTB domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3155"}], "href": "https://doi.org/10.1038/nsmb.3155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26779609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26779609"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "F F Golyan, T E Druley, M R Abbaszadegan "}, {"type": "b", "children": [{"type": "t", "text": "Whole-exome sequencing of familial esophageal squamous cell carcinoma identified rare pathogenic variants in new predisposition genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-019-02174-z"}], "href": "https://doi.org/10.1007/s12094-019-02174-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31321674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31321674"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ryong Nam Kim, Aeri Kim, Dong-Wook Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Genet (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22552337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22552337"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hui-Ling Huang, Yu-Chung Wu, Li-Jen Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of prognostic biomarkers for predicting lung cancer metastasis using microarray and survival data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Bioinformatics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12859-015-0463-x"}], "href": "https://doi.org/10.1186/s12859-015-0463-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25881029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25881029"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xianhong Yang, Rui Qiao, Nana Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome Wide Differential Expression Profiles in Nevus Sebaceous Uncovered Low Expression of CDKN2AIP and Construction of a ceRNA Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cosmet Investig Dermatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CCID.S357755"}], "href": "https://doi.org/10.2147/CCID.S357755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35368624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35368624"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sunitha Meruvu, Jian Zhang, Mahua Choudhury "}, {"type": "b", "children": [{"type": "t", "text": "Mono-(2-ethylhexyl) Phthalate Increases Oxidative Stress Responsive miRNAs in First Trimester Placental Cell Line HTR8/SVneo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chem Res Toxicol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.chemrestox.6b00038"}], "href": "https://doi.org/10.1021/acs.chemrestox.6b00038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26871967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26871967"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xiaoli He, Wenjuan Zhang, Chen Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Discov (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/celldisc.2017.3"}], "href": "https://doi.org/10.1038/celldisc.2017.3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28417011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28417011"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Quanshun Mei, Chuanke Fu, Goutam Sahana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of new semen trait-related candidate genes in Duroc boars through genome-wide association and weighted gene co-expression network analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Anim Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jas/skab188"}], "href": "https://doi.org/10.1093/jas/skab188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34110414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34110414"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Haiping Zhang, Ziliang Yu, Bingbing Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1989258"}], "href": "https://doi.org/10.1080/21655979.2021.1989258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34637672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34637672"}]}]}]}
Synonyms	CARF
Proteins	CARF_HUMAN
NCBI Gene ID	55602
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CDKN2AIP has 6,530 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for CDKN2AIP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CDKN2AIP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDKN2AIP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDKN2AIP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CDKN2AIP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CDKN2AIP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CDKN2AIP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CDKN2AIP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CDKN2AIP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDKN2AIP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CDKN2AIP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CDKN2AIP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDKN2AIP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CDKN2AIP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CDKN2AIP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CDKN2AIP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDKN2AIP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CDKN2AIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CDKN2AIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CDKN2AIP protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CDKN2AIP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CDKN2AIP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CDKN2AIP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CDKN2AIP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CDKN2AIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CDKN2AIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CDKN2AIP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CDKN2AIP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CDKN2AIP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CDKN2AIP gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CDKN2AIP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CDKN2AIP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CDKN2AIP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CDKN2AIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CDKN2AIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CDKN2AIP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CDKN2AIP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CDKN2AIP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CDKN2AIP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CDKN2AIP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CDKN2AIP from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CDKN2AIP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.