CEACAM1 Gene

HGNC Family	Carcinoembryonic antigen family (CEACAM, PSG), Immunoglobulin superfamily domain containing, CD molecules (CD)
Name	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Description	This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is emerging as a multifaceted regulator with roles spanning immune modulation, metabolic control, tissue morphogenesis, and tumor progression. In immune cells, CEACAM1 functions as a key negative regulator: it forms heterodimers with molecules such as TIM‐3, thereby promoting the maturation, cell surface expression, and inhibitory capacity of this receptor on T cells. These interactions contribute to the dampening of Th1 responses and the induction of tolerance in both peripheral and mucosal settings, including within decidual lymphocytes where CEACAM1 engagement inhibits lysis, proliferation, and cytokine secretion (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In parallel, CEACAM1 is implicated in mediating natural killer cell inhibition by both homophilic interactions and heterophilic binding with members of the CEA family, contributing to tumor immune evasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond immunomodulation, CEACAM1 plays a critical role in metabolic homeostasis. In hepatocytes, insulin‐stimulated phosphorylation of CEACAM1 enhances receptor‐mediated insulin uptake and degradation, which is central to maintaining insulin sensitivity and preventing hyperinsulinemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, as a receptor for microbial adhesins such as those expressed by Helicobacter pylori, CEACAM1 binding facilitates the translocation of virulence factors into host cells, thereby participating in the modulation of host–pathogen interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of tissue organization and cancer, CEACAM1 influences both morphogenesis and tumor cell behavior. Its expression is essential for proper acinar lumen formation in breast epithelial models, where the CEACAM1‐4S isoform mediates apoptosis of central cells to generate lumena."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In melanoma and other cancers, increased CEACAM1 expression at tumor invasion fronts correlates with enhanced migration, invasion, and a higher risk of metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these findings underscore the central role of CEACAM1 as an adhesion molecule and regulatory co‐receptor that integrates signaling pathways controlling immune responses, metabolic regulation, and cellular architecture, with significant implications for autoimmunity, infection, and cancer progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu-Hwa Huang, Chen Zhu, Yasuyuki Kondo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CEACAM1 regulates TIM-3-mediated tolerance and exhaustion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature13848"}], "href": "https://doi.org/10.1038/nature13848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25363763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25363763"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Atsushi Nakajima, Hideki Iijima, Markus F Neurath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.168.3.1028"}], "href": "https://doi.org/10.4049/jimmunol.168.3.1028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11801635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11801635"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gal Markel, Dana Wolf, Jacob Hanna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI15643"}], "href": "https://doi.org/10.1172/JCI15643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12370272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12370272"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Scott D Gray-Owen, Richard S Blumberg "}, {"type": "b", "children": [{"type": "t", "text": "CEACAM1: contact-dependent control of immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nri1864"}], "href": "https://doi.org/10.1038/nri1864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16724098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16724098"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Noam Stern, Gal Markel, Tal I Arnon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.174.11.6692"}], "href": "https://doi.org/10.4049/jimmunol.174.11.6692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15905509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15905509"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Matthew N Poy, Yan Yang, Khadijeh Rezaei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CEACAM1 regulates insulin clearance in liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng840"}], "href": "https://doi.org/10.1038/ng840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11850617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11850617"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anahita Javaheri, Tobias Kruse, Kristof Moonens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nmicrobiol.2016.189"}], "href": "https://doi.org/10.1038/nmicrobiol.2016.189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27748768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27748768"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Julia Kirshner, Charng-Jui Chen, Pingfang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.232711199"}], "href": "https://doi.org/10.1073/pnas.232711199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12522268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12522268"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Anka Thies, Ingrid Moll, Jürgen Berger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2002.05.033"}], "href": "https://doi.org/10.1200/JCO.2002.05.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12011132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12011132"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Alireza Ebrahimnejad, Thomas Streichert, Peter Nollau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CEACAM1 enhances invasion and migration of melanocytic and melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0002-9440(10)63433-5"}], "href": "https://doi.org/10.1016/S0002-9440(10"}, {"type": "t", "text": "63433-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15509546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15509546"}]}]}]}
Synonyms	BGPI, BGP1
Proteins	CEAM1_HUMAN
NCBI Gene ID	634
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CEACAM1 has 9,667 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 113 datasets.

Click the + buttons to view associations for CEACAM1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CEACAM1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CEACAM1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEACAM1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEACAM1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CEACAM1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CEACAM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEACAM1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CEACAM1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CEACAM1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CEACAM1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CEACAM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CEACAM1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CEACAM1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CEACAM1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CEACAM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CEACAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CEACAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CEACAM1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CEACAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CEACAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CEACAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CEACAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CEACAM1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CEACAM1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CEACAM1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CEACAM1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CEACAM1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CEACAM1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CEACAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CEACAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CEACAM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CEACAM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for CEACAM1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CEACAM1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CEACAM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CEACAM1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CEACAM1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CEACAM1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CEACAM1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CEACAM1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CEACAM1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.