CEBPB Gene

HGNC Family	Basic leucine zipper proteins
Name	CCAAT/enhancer binding protein (C/EBP), beta
Description	This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n C/EBPβ is a multifunctional transcription factor that plays pivotal roles in regulating cell fate decisions, metabolism, inflammation, and tumorigenesis. In adipogenesis, C/EBPβ is induced early in differentiating cells, where its timely activation—and notably the balance between its transcriptionally active (LAP) and inhibitory (LIP) isoforms—is critical for triggering mitotic clonal expansion and subsequently activating downstream effectors such as C/EBPα and PPARγ, processes essential for proper adipocyte differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Translational control mechanisms, including those involving upstream open reading frames and signaling via the PKR and mTOR pathways, further modulate the relative abundance of C/EBPβ isoforms to fine‐tune its transcriptional output."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the context of cancer, C/EBPβ collaborates with factors such as STAT3 to induce a mesenchymal gene expression program that promotes aggressive behavior in tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, during cellular senescence, C/EBPβ contributes to the establishment of a secretory phenotype by regulating chemokine expression, thereby reinforcing growth arrest and influencing inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings underscore the versatility of C/EBPβ as an integrator of translational and transcriptional regulatory networks that determine cell identity and function in both physiological and pathological contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qi-Qun Tang, Tamara C Otto, M Daniel Lane "}, {"type": "b", "children": [{"type": "t", "text": "CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0337434100"}], "href": "https://doi.org/10.1073/pnas.0337434100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12525691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12525691"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2004.11.005"}], "href": "https://doi.org/10.1016/j.cmet.2004.11.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16054042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16054042"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "P Descombes, U Schibler "}, {"type": "b", "children": [{"type": "t", "text": "A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (1991)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0092-8674(91)90531-3"}], "href": "https://doi.org/10.1016/0092-8674(91"}, {"type": "t", "text": "90531-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "1934061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/1934061"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C F Calkhoven, C Müller, A Leutz "}, {"type": "b", "children": [{"type": "t", "text": "Translational control of C/EBPalpha and C/EBPbeta isoform expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2000)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10921906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10921906"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maria Stella Carro, Wei Keat Lim, Mariano Javier Alvarez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional network for mesenchymal transformation of brain tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08712"}], "href": "https://doi.org/10.1038/nature08712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20032975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20032975"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Justin Lamb, Sridhar Ramaswamy, Heide L Ford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00570-1"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00570-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12914697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12914697"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Juan C Acosta, Ana O'Loghlen, Ana Banito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemokine signaling via the CXCR2 receptor reinforces senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2008.03.038"}], "href": "https://doi.org/10.1016/j.cell.2008.03.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18555777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18555777"}]}]}]}
Synonyms	TCF5, C/EBP-BETA, IL6DBP, NF-IL6
Proteins	CEBPB_HUMAN
NCBI Gene ID	1051
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CEBPB has 14,220 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for CEBPB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CEBPB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEBPB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CEBPB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CEBPB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEBPB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving CEBPB protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CEBPB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CEBPB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CEBPB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CEBPB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CEBPB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CEBPB protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CEBPB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CEBPB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CEBPB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CEBPB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CEBPB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CEBPB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CEBPB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CEBPB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CEBPB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CEBPB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CEBPB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CEBPB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CEBPB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CEBPB gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CEBPB protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CEBPB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CEBPB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CEBPB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CEBPB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CEBPB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CEBPB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CEBPB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CEBPB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CEBPB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CEBPB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CEBPB gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CEBPB gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CEBPB gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CEBPB from the GeneSigDB Published Gene Signatures dataset.