CEBPE Gene

HGNC Family	Basic leucine zipper proteins
Name	CCAAT/enhancer binding protein (C/EBP), epsilon
Description	The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CCAAT/enhancer binding protein ε (CEBPE) is emerging as a pivotal transcriptional regulator in myeloid differentiation and immune function. Its activity is critical for the terminal differentiation of granulocytes, as evidenced by studies demonstrating that proper expression of CEBPE is essential for inducing the full complement of neutrophil secondary and tertiary granule proteins necessary for mature neutrophil function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, analyses of distinct CEBPE isoforms in hematopoietic progenitors have uncovered that activator forms can drive eosinophil-specific gene expression, whereas repressor isoforms interfere with GATA‐1/PU.1 synergy, thereby modulating lineage commitment between eosinophilic and neutrophilic fates."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genome‐wide association studies further implicate CEBPE in leukemogenesis; common germline variants at the CEBPE locus are associated with an increased risk of childhood acute lymphoblastic leukemia, highlighting its key role in regulating the transcriptional programs of B‐cell progenitors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, oncogenic pathways can disrupt normal CEBPE function. For example, the aberrant binding of the EVI1 oncoprotein to regulatory regions and subsequent downregulation of CEBPE perturbs terminal myeloid differentiation, thereby contributing to leukemic transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n CEBPE also participates in broader transcription factor networks that govern myeloid cell fate, such as its interaction with the chromatin remodeling factor SMARCD2, which is required for the expression of neutrophil granule proteins; external signals like vitamin D further influence CEBPE expression in monocytes, linking it to inflammatory and immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that CEBPE is critical for orchestrating the transcriptional programs underlying granulocytic maturation and immune competence, while its dysregulation is implicated in hematologic malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Adrian F Gombart, Scott H Kwok, Karen L Anderson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-04-1039"}], "href": "https://doi.org/10.1182/blood-2002-04-1039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12515729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12515729"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Richa Bedi, Jian Du, Arun K Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human C/EBP-epsilon activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-02-139741"}], "href": "https://doi.org/10.1182/blood-2008-02-139741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18832658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18832658"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jian Du, Monika J Stankiewicz, Yang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M204777200"}], "href": "https://doi.org/10.1074/jbc.M204777200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12202480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12202480"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elli Papaemmanuil, Fay J Hosking, Jayaram Vijayakrishnan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.430"}], "href": "https://doi.org/10.1038/ng.430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19684604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19684604"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Carolyn Glass, Charles Wuertzer, Xiaohui Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0067134"}], "href": "https://doi.org/10.1371/journal.pone.0067134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23826213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23826213"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Maximilian Witzel, Daniel Petersheim, Yanxin Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3833"}], "href": "https://doi.org/10.1038/ng.3833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28369036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28369036"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dov Tiosano, Gizi Wildbaum, Vardit Gepstein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of vitamin D receptor in innate and adaptive immunity: a study in hereditary vitamin D-resistant rickets patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2012-3858"}], "href": "https://doi.org/10.1210/jc.2012-3858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23482605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23482605"}]}]}]}
Synonyms	C/EBP-EPSILON, CRP1
Proteins	CEBPE_HUMAN
NCBI Gene ID	1053
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CEBPE has 5,114 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for CEBPE from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CEBPE Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEBPE gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEBPE gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CEBPE gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CEBPE gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEBPE gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CEBPE gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CEBPE gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CEBPE gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CEBPE gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CEBPE gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CEBPE gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CEBPE gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CEBPE gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CEBPE gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CEBPE gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CEBPE gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of CEBPE gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CEBPE gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CEBPE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CEBPE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CEBPE protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CEBPE protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CEBPE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CEBPE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CEBPE protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CEBPE gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CEBPE gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CEBPE gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CEBPE gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CEBPE gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CEBPE gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CEBPE gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CEBPE gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CEBPE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CEBPE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CEBPE gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CEBPE gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CEBPE gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CEBPE gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CEBPE gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.