CEBPZOS Gene

Name CEBPZ opposite strand
Description Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have provided insights into proteins that help maintain mitochondrial gene expression during cellular stress. In one investigation, a protein originally annotated as C6orf203 and renamed MTRES1 was shown to act as a mitochondrial transcription rescue factor. Under stress conditions that reduce mitochondrial genome copy number, the level of MTRES1 increases, and its RNA‐binding activity enables it to associate with the mitochondrial RNA polymerase (POLRMT) to stimulate transcription. This activity prevents the loss of mitochondrial transcripts without altering their stability, thereby supporting mitochondrial gene expression and overall cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, an advanced proteomic analysis using an engineered peroxidase combined with a SILAC‐based ratiometric tagging strategy was applied to map proteins within the mitochondrial intermembrane space. This approach, which offers nanometer spatial resolution and high specificity, enabled the identification of numerous mitochondrial proteins, including several that were previously uncharacterized. Although this second study does not focus directly on the function of MTRES1/CEBPZOS, it highlights the utility of innovative proteomic strategies to dissect mitochondrial organization and identify novel components that could intersect with regulatory mechanisms safeguarding mitochondrial transcription in stressed cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anna V Kotrys, Dominik Cysewski, Sylwia D Czarnomska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz542"}], "href": "https://doi.org/10.1093/nar/gkz542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31226201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31226201"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Victoria Hung, Peng Zou, Hyun-Woo Rhee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2014.06.003"}], "href": "https://doi.org/10.1016/j.molcel.2014.06.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25002142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25002142"}]}]}]}
Synonyms CEBPZ-AS1
Proteins CEBOS_HUMAN
NCBI Gene ID 100505876
API
Download Associations
Predicted Functions View CEBPZOS's ARCHS4 Predicted Functions.
Co-expressed Genes View CEBPZOS's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View CEBPZOS's ARCHS4 Predicted Functions.

Functional Associations

CEBPZOS has 1,683 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 34 datasets.

Click the + buttons to view associations for CEBPZOS from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of CEBPZOS gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of CEBPZOS gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of CEBPZOS gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with CEBPZOS gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of CEBPZOS gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of CEBPZOS gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with CEBPZOS protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of CEBPZOS protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with CEBPZOS gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of CEBPZOS gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of CEBPZOS gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GTEx eQTL 2025 SNPs regulating expression of CEBPZOS gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of CEBPZOS gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of CEBPZOS gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of CEBPZOS gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of CEBPZOS gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of CEBPZOS gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of CEBPZOS gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of CEBPZOS gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of CEBPZOS gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of CEBPZOS gene from the NIBR DRUG-seq U2OS MoA Box dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of CEBPZOS gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of CEBPZOS gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of CEBPZOS gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of CEBPZOS gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of CEBPZOS gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of CEBPZOS gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of CEBPZOS gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of CEBPZOS gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with CEBPZOS protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of CEBPZOS gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of CEBPZOS gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of CEBPZOS protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with CEBPZOS protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.