{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CEMIP (also known as KIAA1199 or HYBID) is a multifunctional protein with a central role in the degradation of hyaluronan—a key glycosaminoglycan of the extracellular matrix—thereby modulating tissue remodeling under both physiological and pathological conditions. Its hyaluronan‐depolymerizing activity has been shown to promote cell migration, invasion, and metastasis across a range of cancers including brain metastases from breast tumors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", colorectal"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": ", gastric"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", pancreatic"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", ovarian"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", non‐small cell lung"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and breast cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, CEMIP influences several oncogenic signaling cascades—including Wnt/β‐catenin, PI3K/AKT, and EGFR pathways—thereby facilitating epithelial–mesenchymal transition and enhancing cell survival under stressful conditions such as hypoxia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Moreover, its expression is regulated by diverse factors including microRNAs and inflammatory stimuli, which further contribute to its role in promoting metastatic behavior. In addition to its well‐established functions in cancer progression, rare mutations in CEMIP have been linked to nonsyndromic hearing loss, suggesting that its activity in hyaluronan turnover is also critical for normal tissue function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, the collective evidence positions CEMIP as a promising prognostic biomarker and therapeutic target in cancer and other diseases where aberrant extracellular matrix remodeling plays a crucial role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_fs", "start_ref": "7", "end_ref": "9"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gonçalo Rodrigues, Ayuko Hoshino, Candia M Kenific, et al. 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