CENPC Gene

Name	centromere protein C
Description	Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>CENP‑C Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n CENP‑C is a highly conserved core component of centromeric chromatin that functions as an architectural scaffold to coordinate centromere integrity and kinetochore assembly. By directly binding to CENP‑A–containing nucleosomes, CENP‑C both remodels nucleosome structure to stabilize the epigenetic mark that defines centromere identity and promotes a chromatin configuration conducive to kinetochore formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Its N‐terminal region contains a conserved motif that directly binds the Mis12 complex, thereby physically linking the inner centromere to the outer kinetochore, which is essential for robust microtubule attachment and accurate chromosome segregation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, CENP‑C serves as a platform for recruiting key centromere–targeting factors: interactions with the histone chaperone HJURP and with M18BP1 facilitate de novo CENP‑A deposition and centromere propagation, while its association with centromeric satellite RNA helps regulate its nucleolar localization during interphase to ensure timely release for kinetochore assembly."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " In addition, through its physical interactions with other factors that safeguard chromosomal architecture, CENP‑C indirectly contributes to the maintenance of genomic stability and proper DNA repair."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these studies establish CENP‑C as an essential blueprint for centromere specification, integrating specific chromatin modifications with kinetochore assembly pathways to ensure accurate chromosome segregation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Samantha J Falk, Lucie Y Guo, Nikolina Sekulic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1259308"}], "href": "https://doi.org/10.1126/science.1259308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25954010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25954010"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chikashi Obuse, Hua Yang, Naohito Nozaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2004.00705.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2004.00705.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15009096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15009096"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pim J Huis In 't Veld, Sadasivam Jeganathan, Arsen Petrovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular basis of outer kinetochore assembly on CENP-T."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.21007"}], "href": "https://doi.org/10.7554/eLife.21007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28012276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28012276"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Emanuela Screpanti, Anna De Antoni, Gregory M Alushin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2010.12.039"}], "href": "https://doi.org/10.1016/j.cub.2010.12.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21353556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21353556"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kerstin Klare, John R Weir, Federica Basilico, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201412028"}], "href": "https://doi.org/10.1083/jcb.201412028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26124289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26124289"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lee H Wong, Kate H Brettingham-Moore, Lyn Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.6022807"}], "href": "https://doi.org/10.1101/gr.6022807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17623812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17623812"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hiroaki Tachiwana, Sebastian Müller, Julia Blümer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2015.03.013"}], "href": "https://doi.org/10.1016/j.celrep.2015.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25843710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25843710"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Silvia Dambacher, Wen Deng, Matthias Hahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleus (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/nucl.18955"}], "href": "https://doi.org/10.4161/nucl.18955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22540025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22540025"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wen Hong Shen, Adayabalam S Balajee, Jianli Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for nuclear PTEN in maintaining chromosomal integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2006.11.042"}], "href": "https://doi.org/10.1016/j.cell.2006.11.042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17218262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17218262"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Daniel R Foltz, Lars E T Jansen, Ben E Black, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human CENP-A centromeric nucleosome-associated complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1397"}], "href": "https://doi.org/10.1038/ncb1397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16622419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16622419"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tetsuya Hori, Miho Amano, Aussie Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2008.10.019"}], "href": "https://doi.org/10.1016/j.cell.2008.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19070575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19070575"}]}]}]}
Synonyms	HCP-4, CENP-C, CENPC1, MIF2
Proteins	CENPC_HUMAN
NCBI Gene ID	1060
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CENPC has 5,766 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for CENPC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CENPC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CENPC gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CENPC gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CENPC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CENPC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CENPC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CENPC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CENPC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CENPC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CENPC gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CENPC gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CENPC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CENPC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CENPC protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CENPC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CENPC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CENPC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CENPC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CENPC protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CENPC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CENPC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CENPC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CENPC protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CENPC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CENPC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CENPC protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CENPC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CENPC gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CENPC gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CENPC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CENPC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CENPC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CENPC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CENPC gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CENPC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CENPC gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CENPC from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CENPC gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CENPC gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CENPC gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CENPC gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.