CEP63 Gene

Name	centrosomal protein 63kDa
Description	This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCEP63 is a pivotal centrosomal protein that localizes at the proximal end of centrioles and partners with other centrosomal components—including CEP57 and CEP152—to form a ring‐like, self‐assembling, cylindrical scaffold within the pericentriolar material. This elegant architecture is essential for organizing the centrosome and ensuring the faithful duplication of centrioles, as demonstrated by studies using chemical crosslinking and super‐resolution imaging, which delineated its cooperative assembly with CEP152 into a heterotetrameric α‐helical bundle that recruits pivotal regulators such as Plk4."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its structural role, CEP63 is critical for the regulation of the cell cycle. It functions by recruiting regulators such as Cdk1 to the centrosome, thereby promoting timely mitotic entry, while its overexpression can lead to de novo centrosome amplification and mitotic abnormalities. Moreover, structural alterations—including deleterious nonsynonymous single nucleotide polymorphisms that increase the flexibility of its three‐dimensional conformation—disrupt the proper recruitment of other essential centrosomal proteins, with consequential effects on spindle assembly and the maintenance of genomic integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrations in CEP63 not only compromise centrosome function but are also linked to a spectrum of human diseases. A mutation in CEP63 has been associated with developmental dyslexia, underscoring its importance during brain development, while genetic variations and deregulated expression of CEP63 have been reported in several cancers—including colorectal cancer, papillary thyroid carcinoma, and brain tumors—where they correlate with altered cell proliferation, impaired apoptosis through pathways such as JAK/STAT3 and Bcl‐2/BAX, and overall poor clinical prognosis. Collectively, these findings point to CEP63 as a key mediator of centrosome assembly and cell cycle control, whose dysregulation may drive tumorigenesis and developmental disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gražvydas Lukinavičius, Darja Lavogina, Meritxell Orpinell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2012.12.030"}], "href": "https://doi.org/10.1016/j.cub.2012.12.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23333316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23333316"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nicola J Brown, Marko Marjanović, Jens Lüders, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cep63 and cep152 cooperate to ensure centriole duplication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0069986"}], "href": "https://doi.org/10.1371/journal.pone.0069986"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23936128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23936128"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tae-Sung Kim, Liang Zhang, Jong Il Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular architecture of a cylindrical self-assembly at human centrosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-08838-2"}], "href": "https://doi.org/10.1038/s41467-019-08838-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30858376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30858376"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhuang Wei, Tae-Sung Kim, Jong Il Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00535-19"}], "href": "https://doi.org/10.1128/MCB.00535-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32152252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32152252"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Harald Löffler, Anne Fechter, Marc Matuszewska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-2684"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-2684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21406398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21406398"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ambuj Kumar, Rituraj Purohit "}, {"type": "b", "children": [{"type": "t", "text": "Computational investigation of pathogenic nsSNPs in CEP63 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2012.04.032"}], "href": "https://doi.org/10.1016/j.gene.2012.04.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22555018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22555018"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Elisabet Einarsdottir, Idor Svensson, Fahimeh Darki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-015-1602-1"}], "href": "https://doi.org/10.1007/s00439-015-1602-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26400686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26400686"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "H Kubra Gurkaslar, Efraim Culfa, Melis D Arslanhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.107630"}], "href": "https://doi.org/10.1016/j.celrep.2020.107630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32402286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32402286"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Han Ling, Chen-Hui Cao, Kai Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-022-02439-y"}], "href": "https://doi.org/10.1038/s41388-022-02439-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35989368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35989368"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chenguang Liu, Fangqin Yu, Runsheng Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8150"}], "href": "https://doi.org/10.3892/or.2021.8150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34296302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34296302"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "C G Liu, F Q Yu, R S Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Study on "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Cep63"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn115330-20200610-00490"}], "href": "https://doi.org/10.3760/cma.j.cn115330-20200610-00490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33472304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33472304"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ishrat Mahjabeen, Yusra Maqsood, Ramsha Abbasi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphism in miRNA target sites of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "CEP-63"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "CEP-152"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " ring complex influences expression of CEP genes and favors tumorigenesis in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2020-1034"}], "href": "https://doi.org/10.2217/fon-2020-1034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34156311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34156311"}]}]}]}
Synonyms	SCKL6
Proteins	CEP63_HUMAN
NCBI Gene ID	80254
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CEP63 has 5,604 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for CEP63 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CEP63 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEP63 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEP63 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CEP63 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CEP63 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CEP63 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CEP63 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CEP63 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CEP63 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CEP63 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CEP63 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CEP63 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CEP63 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CEP63 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CEP63 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CEP63 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CEP63 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CEP63 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CEP63 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CEP63 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CEP63 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CEP63 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CEP63 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CEP63 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CEP63 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CEP63 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CEP63 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CEP63 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CEP63 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CEP63 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CEP63 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CEP63 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CEP63 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CEP63 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving CEP63 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CEP63 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CEP63 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CEP63 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CEP63 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CEP63 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CEP63 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.