{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CFAP157 is a novel component of the FOXJ1‐regulated genetic program essential for the formation and function of motile cilia. Specifically, CFAP157 is expressed in the motile ciliated tissues of vertebrates, where it localizes to basal bodies and interacts with key cytoskeletal elements such as tubulin and the centrosomal protein CEP350. During spermiogenesis, CFAP157 plays a critical role by ensuring the proper assembly of the sperm flagellar axoneme; it prevents the formation of supernumerary axonemal structures and suppresses structural aberrations such as axonemal loops and excessive cytoplasmic retention. Although Cfap157 knockout mice display an overall normal phenotype, the resulting defective sperm ultrastructure leads to impaired motility and male infertility, underscoring its sperm‐specific function in maintaining correct ultrastructural organization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marina Weidemann, Karin Schuster-Gossler, Michael Stauber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.139626"}], "href": "https://doi.org/10.1242/dev.139626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27965440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27965440"}]}]}]}