{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CFAP206 encodes a microtubule‐docking adapter that is essential for the proper assembly and stability of critical ciliary and flagellar structures. In spermatozoa, CFAP206 is required for anchoring components such as the radial spoke and inner dynein arm to the microtubule axoneme. Its normal function ensures flagellum integrity, contributing directly to effective sperm motility. Loss‐of‐function mutations or deletions in CFAP206 result in severe morphological and ultrastructural defects of the sperm flagellum, leading to impaired motility and male infertility in both human and mouse models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Additionally, in the context of chronic alcohol exposure in the developing brain, CFAP206 expression is upregulated alongside other genes associated with cilium movement, suggesting that its role in modulating ciliary function may extend beyond the reproductive system to influence neuronal processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qunshan Shen, Guillaume Martinez, Hongbin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-021-02313-z"}], "href": "https://doi.org/10.1007/s00439-021-02313-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34255152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34255152"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mi Ran Choi, Jasmin Sanghyun Han, Young Gyu Chai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression profiling in the hippocampus of adolescent rats after chronic alcohol administration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Basic Clin Pharmacol Toxicol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bcpt.13342"}], "href": "https://doi.org/10.1111/bcpt.13342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31628824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31628824"}]}]}]}