{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The gene CFAP77—named for its membership in the “cilia and flagella associated protein” family—has been implicated in functions related to cellular projections. In one study addressing opioid dependence, an epigenome‐wide association analysis identified differential methylation at CpG sites in several genes, among which CFAP77 was found to be significant. Functional annotations provided in that study grouped CFAP77 with processes such as chromatin remodeling, DNA binding, cell survival, and notably, cell projection (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Given its designation and association with cell projection, CFAP77 is likely to play a role in the formation or maintenance of specialized cellular structures, such as cilia and flagella, which are essential for signal transduction and proper cellular function. Although the other abstracts focus on topics such as genomic mappability"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", sex‐related differences in DNA methylation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and the proteomic compositions of airway cilia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the evidence from these varied analyses supports the view that proteins involved in ciliary structure and cell projection may have broader implications in both cellular architecture and disease processes. In the context of opioid dependence, the altered methylation status of CFAP77 points toward a potential epigenetic influence on its role in cell projection, which could affect neuronal connectivity or signaling pathways critical for cell survival.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Janitza L Montalvo-Ortiz, Zhongshan Cheng, Henry R Kranzler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-41110-7"}], "href": "https://doi.org/10.1038/s41598-019-41110-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30874594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30874594"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wentian Li, Jan Freudenberg, Pedro Miramontes "}, {"type": "b", "children": [{"type": "t", "text": "Diminishing return for increased Mappability with longer sequencing reads: implications of the k-mer distributions in the human genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Bioinformatics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2105-15-2"}], "href": "https://doi.org/10.1186/1471-2105-15-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24386976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24386976"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mikio Watanabe, Chika Honda, Yoshinori Iwatani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-016-0217-2"}], "href": "https://doi.org/10.1186/s12920-016-0217-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27561550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27561550"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kevin Blackburn, Ximena Bustamante-Marin, Weining Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.6b00972"}], "href": "https://doi.org/10.1021/acs.jproteome.6b00972"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28282151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28282151"}]}]}]}