CHCHD2 Gene

HGNC Family	Coiled-coil-helix-coiled-coil-helix domain containing (CHCHD)
Name	coiled-coil-helix-coiled-coil-helix domain containing 2
Description	The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CHCHD2 (also known as MNRR1) is a multifunctional mitochondrial protein that plays key roles in maintaining mitochondrial integrity and cellular homeostasis. In the mitochondrial intermembrane space, CHCHD2 binds to cytochrome c oxidase (COX) to promote optimal oxidative phosphorylation, and its activity is modulated by post‐translational modifications (for example, tyrosine phosphorylation) that enhance respiratory function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Under conditions of cellular stress, CHCHD2 translocates to the nucleus where it acts as a transcriptional activator—for instance, promoting expression of the hypoxia-inducible COX4I2 gene—to help cells adapt to low oxygen tensions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, CHCHD2 contributes to the regulation of apoptosis by binding to anti-apoptotic proteins (such as Bcl-xL) and inhibiting the mitochondrial accumulation and oligomerization of pro-apoptotic proteins like Bax, thereby preventing premature mitochondrial outer membrane permeabilization and cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its bioenergetic and anti-apoptotic functions, CHCHD2 interacts and heterodimerizes with its paralog CHCHD10 to maintain mitochondrial cristae organization and ensure efficient electron transport."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Disruption of these interactions—as observed with disease-associated mutations—leads to impaired solubility, increased production of reactive oxygen species, and apoptotic cell death, events that likely contribute to the pathogenesis of Parkinson’s disease and other neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Furthermore, overexpression of CHCHD2 has been linked to enhanced cell migration in vitro and is found upregulated in various cancers, implicating it in tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore CHCHD2’s role as a bi-organellar regulator that coordinates mitochondrial respiration, modulates apoptotic signaling, and even influences gene expression and cell migration, thereby linking its dysfunction to both neurodegenerative conditions and cancer. Mutations in CHCHD2 contribute to the etiology of autosomal dominant Parkinson’s disease by impairing mitochondrial function and promoting cellular stress responses, while its altered expression also serves as a potential biomarker and therapeutic target in malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Siddhesh Aras, Oleg Pak, Natascha Sommer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gks1454"}], "href": "https://doi.org/10.1093/nar/gks1454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23303788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23303788"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Joshua M Baughman, Roland Nilsson, Vishal M Gohil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000590"}], "href": "https://doi.org/10.1371/journal.pgen.1000590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19680543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19680543"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Siddhesh Aras, Hassan Arrabi, Neeraja Purandare, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2016.11.029"}], "href": "https://doi.org/10.1016/j.bbamcr.2016.11.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27913209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27913209"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Siddhesh Aras, Minbo Bai, Icksoo Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mitochondrion (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mito.2014.10.003"}], "href": "https://doi.org/10.1016/j.mito.2014.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25315652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25315652"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Siddhesh Aras, Neeraja Purandare, Stephanie Gladyck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2005877117"}], "href": "https://doi.org/10.1073/pnas.2005877117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33257573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33257573"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Y Liu, H V Clegg, P L Leslie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2014.194"}], "href": "https://doi.org/10.1038/cdd.2014.194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25476776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25476776"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "S R Burstein, F Valsecchi, H Kawamata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx397"}], "href": "https://doi.org/10.1093/hmg/ddx397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29112723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29112723"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiaoping Huang, Beverly P Wu, Diana Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddy270"}], "href": "https://doi.org/10.1093/hmg/ddy270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30084972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30084972"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wei Zhou, Dongrui Ma, Alfred Xuyang Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddy413"}], "href": "https://doi.org/10.1093/hmg/ddy413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30496485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30496485"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tom Cornelissen, Marco Spinazzi, Shaun Martin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHCHD2 harboring Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddaa028"}], "href": "https://doi.org/10.1093/hmg/ddaa028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32068847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32068847"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Aya Ikeda, Kenya Nishioka, Hongrui Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in CHCHD2 cause α-synuclein aggregation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddz241"}], "href": "https://doi.org/10.1093/hmg/ddz241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31600778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31600778"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Minchul Seo, Won-Ha Lee, Kyoungho Suk "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel cell migration-promoting genes by a functional genetic screen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.09-137562"}], "href": "https://doi.org/10.1096/fj.09-137562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19812375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19812375"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yuhong Wei, Ravi N Vellanki, Étienne Coyaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-14-0165-T"}], "href": "https://doi.org/10.1158/1541-7786.MCR-14-0165-T"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25784717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25784717"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xin Yin, Jinghua Xia, Ying Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Pulm Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12890-020-1079-0"}], "href": "https://doi.org/10.1186/s12890-020-1079-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32054470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32054470"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Siddhesh Aras, Marie-Claire Maroun, Yeohan Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-019-5575-7"}], "href": "https://doi.org/10.1186/s12885-019-5575-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31046734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31046734"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Manabu Funayama, Kenji Ohe, Taku Amo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lancet Neurol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S1474-4422(14)70266-2"}], "href": "https://doi.org/10.1016/S1474-4422(14"}, {"type": "t", "text": "70266-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25662902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25662902"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Lili Zhu, Aurora Gomez-Duran, Gabriele Saretzki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201601061"}], "href": "https://doi.org/10.1083/jcb.201601061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27810911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27810911"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mai K Nguyen, Kevin McAvoy, Szu-Chi Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddab329"}], "href": "https://doi.org/10.1093/hmg/ddab329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34791217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34791217"}]}]}]}
Synonyms	PARK22, C7ORF17, MIX17B, MNRR1, NS2TP
Proteins	CHCH2_HUMAN
NCBI Gene ID	51142
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CHCHD2 has 8,625 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for CHCHD2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CHCHD2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CHCHD2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CHCHD2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CHCHD2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CHCHD2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CHCHD2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CHCHD2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CHCHD2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CHCHD2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CHCHD2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CHCHD2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CHCHD2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CHCHD2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CHCHD2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CHCHD2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CHCHD2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CHCHD2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CHCHD2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CHCHD2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of CHCHD2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CHCHD2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CHCHD2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CHCHD2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CHCHD2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CHCHD2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CHCHD2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CHCHD2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CHCHD2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CHCHD2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CHCHD2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CHCHD2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CHCHD2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CHCHD2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CHCHD2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CHCHD2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CHCHD2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CHCHD2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CHCHD2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CHCHD2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CHCHD2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CHCHD2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.