CHD8 Gene

Name	chromodomain helicase DNA binding protein 8
Description	This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCHD8 functions as a critical regulator in neural development and is strongly implicated in autism spectrum disorder. Haploinsufficiency of CHD8 disrupts gene‐expression networks involved in synapse formation, neuronal differentiation, and brain patterning. In human neural progenitor cells and cerebral organoid models, reduced CHD8 dosage leads to widespread transcriptional deregulation—including both protein‐coding and noncoding RNAs—which underlies a distinct ASD subtype often associated with macrocephaly, unique facial features, and gastrointestinal complaints."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its neurodevelopmental role, CHD8 modulates Wnt/β‐catenin signaling by directly interacting with β‐catenin and targeting its responsive gene promoters. By recruiting histone H1 to these loci, CHD8 suppresses β‐catenin–dependent transactivation and helps to set a developmental threshold for Wnt responsiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCHD8 is also essential for proper cell cycle progression and transcriptional regulation. It directly regulates G1/S‐phase genes such as CCNE2 and TYMS by binding constitutively to promoter–proximal regions and interacting with elongating RNA polymerase II and E2F transcription factors. Moreover, its association with the U6 small nuclear RNA promoter suggests a broader role in facilitating RNA transcription in eukaryotic cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBiochemical studies reveal that CHD8 exhibits unique chromatin remodeling properties that distinguish it from other CHD family members. It displays DNA–length–dependent binding and nucleosome sliding activity, and it is incorporated into multiprotein complexes—with partners such as BRD4, NSD3, and components of the MLL histone methyltransferase complex—to modulate chromatin structure in a context–dependent manner, including in leukemic cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, CHD8 contributes to oncogenic processes through transcriptional coactivation in various cancers. In prostate cancer, CHD8 directly associates with the androgen receptor to facilitate hormone–responsive gene transcription, while in gastric cancer, reduced CHD8 levels correlate with increased tumor aggressiveness. Furthermore, CHD8 regulates the recruitment of chromatin–modifying factors at key developmental gene promoters, such as HOXA2, underscoring its multifaceted role in bridging chromatin remodeling with gene regulatory networks in both normal development and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tserendulam Batsukh, Lasse Pieper, Anna M Koszucka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq189"}], "href": "https://doi.org/10.1093/hmg/ddq189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20453063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20453063"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Benjamin M Neale, Yan Kou, Li Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Patterns and rates of exonic de novo mutations in autism spectrum disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature11011"}], "href": "https://doi.org/10.1038/nature11011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22495311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22495311"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Raphael Bernier, Christelle Golzio, Bo Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruptive CHD8 mutations define a subtype of autism early in development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.06.017"}], "href": "https://doi.org/10.1016/j.cell.2014.06.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24998929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24998929"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Aarathi Sugathan, Marta Biagioli, Christelle Golzio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1405266111"}], "href": "https://doi.org/10.1073/pnas.1405266111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25294932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25294932"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Justin Cotney, Rebecca A Muhle, Stephan J Sanders, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7404"}], "href": "https://doi.org/10.1038/ncomms7404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25752243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25752243"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "B Wilkinson, N Grepo, B L Thompson, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37566"}], "href": "https://doi.org/10.1002/ajmg.a.37566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26789910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26789910"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Carlo Emanuele Villa, Cristina Cheroni, Christoph P Dotter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2022.110615"}], "href": "https://doi.org/10.1016/j.celrep.2022.110615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35385734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35385734"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Brandi A Thompson, Véronique Tremblay, Grace Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00322-08"}], "href": "https://doi.org/10.1128/MCB.00322-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18378692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18378692"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Masaaki Nishiyama, Arthur I Skoultchi, Keiichi I Nakayama "}, {"type": "b", "children": [{"type": "t", "text": "Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.06409-11"}], "href": "https://doi.org/10.1128/MCB.06409-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22083958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22083958"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chih-Chi Yuan, Xinyang Zhao, Laurence Florens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00846-07"}], "href": "https://doi.org/10.1128/MCB.00846-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17938208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17938208"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "M Rodríguez-Paredes, M Ceballos-Chávez, M Esteller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkp101"}], "href": "https://doi.org/10.1093/nar/gkp101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19255092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19255092"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Alicia Subtil-Rodríguez, Elena Vázquez-Chávez, María Ceballos-Chávez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkt1161"}], "href": "https://doi.org/10.1093/nar/gkt1161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24265227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24265227"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chen Shen, Jonathan J Ipsaro, Junwei Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.10.033"}], "href": "https://doi.org/10.1016/j.molcel.2015.10.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26626481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26626481"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Benjamin J Manning, Timur Yusufzai "}, {"type": "b", "children": [{"type": "t", "text": "The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M117.779470"}], "href": "https://doi.org/10.1074/jbc.M117.779470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28533432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28533432"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Joel A Yates, Tushar Menon, Brandi A Thompson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2010.01.022"}], "href": "https://doi.org/10.1016/j.febslet.2010.01.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20085832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20085832"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Genta Sawada, Hiroki Ueo, Tae Matsumura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHD8 is an independent prognostic indicator that regulates Wnt/β-catenin signaling and the cell cycle in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2013.2597"}], "href": "https://doi.org/10.3892/or.2013.2597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23835524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23835524"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ping Wang, Dejian Zhao, Herbert M Lachman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-017-0058-6"}], "href": "https://doi.org/10.1038/s41398-017-0058-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29317598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29317598"}]}]}]}
Synonyms	HELSNF1, AUTS18
Proteins	CHD8_HUMAN
NCBI Gene ID	57680
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CHD8 has 7,978 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 128 datasets.

Click the + buttons to view associations for CHD8 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CHD8 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CHD8 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CHD8 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CHD8 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CHD8 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CHD8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CHD8 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CHD8 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CHD8 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CHD8 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CHD8 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CHD8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CHD8 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with CHD8 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CHD8 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CHD8 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CHD8 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CHD8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CHD8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CHD8 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CHD8 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CHD8 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CHD8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CHD8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CHD8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CHD8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CHD8 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CHD8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CHD8 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CHD8 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CHD8 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CHD8 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CHD8 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CHD8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CHD8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CHD8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CHD8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CHD8 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CHD8 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CHD8 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CHD8 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.