{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that pseudogenes can play crucial regulatory roles in human cancers. In lung adenocarcinoma (LUAD), an analysis of transcriptional alterations identified four dysregulated pseudogenes with strong prognostic significance, among which CHIAP2 was found to be the most closely associated with patient outcomes. In LUAD tissues, CHIAP2 is abnormally downregulated compared with normal tissues, and its enforced expression significantly impairs tumor cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations using RNA sequencing (RNA-seq) and small RNA-seq further elucidated that overexpression of CHIAP2 leads to the downregulation of six microRNAs. The predicted target genes of these miRNAs are involved in critical pathways, including the WNT signaling cascade. Notably, CHIAP2 appears to exert its tumor-suppressive effects by modulating genes such as NFATC2 and GSK3B through miR-3614-5p and miR-873-3p, thereby impeding LUAD cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Shang, Zhongyu Wang, Wenjie Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pseudogene CHIAP2 inhibits proliferation and invasion of lung adenocarcinoma cells by means of the WNT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28053"}], "href": "https://doi.org/10.1002/jcp.28053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30623445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30623445"}]}]}]}