{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CHMP7 is an ESCRT‐III–related protein that plays a pivotal role in coordinating membrane remodeling events essential for nuclear envelope integrity and endosomal sorting. In dividing cells, CHMP7 is recruited to sites at the reforming nuclear envelope—often through interactions with inner nuclear membrane proteins such as LEM2—to nucleate the assembly of downstream ESCRT‐III components that mediate the sealing of nuclear fenestrations and promote spindle disassembly by facilitating microtubule severing (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " The N‐terminal region of CHMP7 confers a novel membrane‐binding activity that targets it to the endoplasmic reticulum–nuclear envelope continuum, providing a platform for the timely recruitment of ESCRT machinery during both postmitotic nuclear regeneration and repair of ruptured nuclear envelopes (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its central role in nuclear envelope dynamics, CHMP7 contributes to endosomal sorting by interacting with other ESCRT‐III subunits, thereby linking membrane deformation processes at both nuclear and endosomal sites. Its precise spatiotemporal regulation is critical—aberrant accumulation of CHMP7 has been associated with neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), where premature nuclear CHMP7 build‐up precedes nuclear pore complex injury, and with neurodevelopmental disorders including attention‐deficit/hyperactivity disorder (ADHD) (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Studies in yeast and other model organisms further underscore the evolutionarily conserved function of CHMP7: in yeast, an orthologous protein appears to operate at the endoplasmic reticulum to ensure proper membrane remodeling, while analyses in plants reveal that disruption of CHMP7‐related components can adversely affect endosomal sorting and overall cellular homeostasis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings position CHMP7 as a key regulatory hub that links ESCRT‐mediated membrane remodeling at both the nuclear envelope and endosomal compartments, ensuring correct nuclear reassembly, maintenance of genome stability, and proper intracellular trafficking under diverse physiological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marina Vietri, Kay O Schink, Coen Campsteijn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature14408"}], "href": "https://doi.org/10.1038/nature14408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26040712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26040712"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingyu Gu, Dollie LaJoie, Opal S Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1613916114"}], "href": "https://doi.org/10.1073/pnas.1613916114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28242692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28242692"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yolanda Olmos, Anna Perdrix-Rosell, Jeremy G Carlton "}, {"type": "b", "children": [{"type": "t", "text": "Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2016.07.039"}], "href": "https://doi.org/10.1016/j.cub.2016.07.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27618263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27618263"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mio Horii, Hideki Shibata, Ryota Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20060897"}], "href": "https://doi.org/10.1042/BJ20060897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16856878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16856878"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alberto T Gatta, Yolanda Olmos, Caroline L Stoten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK1 controls CHMP7-dependent nuclear envelope reformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.59999"}], "href": "https://doi.org/10.7554/eLife.59999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34286694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34286694"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Alyssa N Coyne, Jeffrey D Rothstein "}, {"type": "b", "children": [{"type": "t", "text": "The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40478-021-01228-0"}], "href": "https://doi.org/10.1186/s40478-021-01228-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34281622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34281622"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Callum Dark, Caitlin Williams, Mark A Bellgrove, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional validation of CHMP7 as an ADHD risk gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-020-01077-w"}], "href": "https://doi.org/10.1038/s41398-020-01077-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33159045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33159045"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Iva Bauer, Thomas Brune, Richard Preiss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for a Nonendosomal Function of the Saccharomyces cerevisiae ESCRT-III-Like Protein Chm7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genetics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1534/genetics.115.178939"}], "href": "https://doi.org/10.1534/genetics.115.178939"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26510789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26510789"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hongli Yang, Jing Liu, Jiulu Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of CHMP7 from rapeseed and Arabidopsis causes dwarfism and premature senescence in Arabidopsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Plant Physiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jplph.2016.06.023"}], "href": "https://doi.org/10.1016/j.jplph.2016.06.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27497741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27497741"}]}]}]}