CIB1 Gene

HGNC Family	EF-hand domain containing
Name	calcium and integrin binding 1 (calmyrin)
Description	This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Calcium and integrin‐binding protein 1 (CIB1) is a 22‐kDa EF‐hand calcium sensor that is widely expressed and functions as a multifunctional regulator linking calcium signaling to diverse cellular processes. Structural studies have shown that CIB1 contains four EF‐hand domains and a hydrophobic pocket that mediates its interactions with multiple effectors, in a manner reminiscent of calmodulin and other neuronal calcium sensor proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cancer cells, CIB1 acts as a Ca²⁺‐dependent myristoyl switch that facilitates the translocation of sphingosine kinase 1 (SK1) to the plasma membrane, thereby promoting sphingosine 1‐phosphate generation and anti‐apoptotic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, CIB1 directly binds to p21‐activated kinase 1 (PAK1), leading to its activation in a calcium‐dependent manner; this interaction modulates actin cytoskeletal dynamics through downstream LIM kinase–cofilin signaling and ultimately regulates cell adhesion and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the context of tumor invasion, CIB1 has also been implicated as an upstream recruiter that, together with regulators such as Rac3 GTPase and the effector GIT1, coordinates the assembly and function of invadopodia—actin‐based protrusions essential for extracellular matrix degradation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Beyond its roles in oncogenic signaling, CIB1 is critical in nontransformed tissues; in the heart, it localizes to the sarcolemma to anchor calcineurin in proximity to L‐type Ca²⁺ channels, thereby modulating calcium‐dependent signaling that contributes to the development of pathological cardiac hypertrophy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Furthermore, genetic deletion of CIB1 in mice results in defects in cell cycle regulation during spermatogenesis—evidenced by reduced testis size, increased germ cell apoptosis, and altered expression of cyclin-dependent regulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings identify CIB1 as a versatile Ca²⁺ sensor that couples extracellular signals to intracellular events governing protein translocation, cytoskeletal reorganization, cell migration, and tissue remodeling, thereby underscoring its potential as a therapeutic target in cancer and cardiac disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Holly R Gentry, Alex U Singer, Laurie Betts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M411515200"}], "href": "https://doi.org/10.1074/jbc.M411515200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15574431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15574431"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kate E Jarman, Paul A B Moretti, Julia R Zebol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.068395"}], "href": "https://doi.org/10.1074/jbc.M109.068395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19854831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19854831"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tina M Leisner, Mingjuan Liu, Zahara M Jaffer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role of CIB1 in regulating PAK1 activation and cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200502090"}], "href": "https://doi.org/10.1083/jcb.200502090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16061695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16061695"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Andrew S McNeal, Kevin Liu, Vihang Nakhate, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-15-0196"}], "href": "https://doi.org/10.1158/2159-8290.CD-15-0196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26183406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26183406"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sara K Donnelly, Ramon Cabrera, Serena P H Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201704048"}], "href": "https://doi.org/10.1083/jcb.201704048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29061650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29061650"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Joerg Heineke, Mannix Auger-Messier, Robert N Correll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CIB1 is a regulator of pathological cardiac hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2181"}], "href": "https://doi.org/10.1038/nm.2181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20639889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20639889"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Weiping Yuan, Tina M Leisner, Andrew W McFadden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CIB1 is essential for mouse spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01488-06"}], "href": "https://doi.org/10.1128/MCB.01488-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16982698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16982698"}]}]}]}
Synonyms	CIBP, SIP2-28, CIB, PRKDCIP
Proteins	CIB1_HUMAN
NCBI Gene ID	10519
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CIB1 has 9,322 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for CIB1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CIB1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CIB1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CIB1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CIB1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CIB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CIB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CIB1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CIB1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CIB1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CIB1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CIB1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CIB1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CIB1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CIB1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CIB1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CIB1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CIB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CIB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CIB1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CIB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CIB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CIB1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CIB1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CIB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CIB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CIB1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CIB1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CIB1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CIB1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CIB1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CIB1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CIB1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CIB1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CIB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CIB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CIB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CIB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CIB1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CIB1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CIB1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CIB1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.