CIRBP Gene

HGNC Family	RNA binding motif containing (RBM)
Name	cold inducible RNA binding protein
Description	Enables mRNA 3'-UTR binding activity and small ribosomal subunit rRNA binding activity. Involved in mRNA stabilization; positive regulation of translation; and response to UV. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cold‐inducible RNA‐binding protein (CIRBP) is a multifaceted stress‐responsive protein that plays critical roles in orchestrating cellular adaptation to diverse environmental challenges and in modulating both proinflammatory and survival pathways. Under conditions of hemorrhagic shock and sepsis, CIRBP is upregulated in various organs, translocates from the nucleus to the cytosol, and is actively released into the circulation. Extracellularly, CIRBP acts as a damage‐associated molecular pattern (DAMP) by directly engaging pattern recognition receptors—including the TLR4–MD2 complex and TREM‑1—to stimulate robust cytokine release (e.g. TNF‑α, IL‑1β, HMGB1), which amplifies systemic inflammatory responses and exacerbates tissue injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its extracellular functions, intracellular CIRBP is dynamically regulated by stress signals such as hypoxia, UV‐irradiation, and mild hypothermia. These stressors promote its relocalization into stress granules, where CIRBP modulates mRNA stability and translation to influence cell survival pathways, including ERK‐mediated antiapoptotic signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " Moreover, CIRBP contributes to the regulation of circadian gene expression by binding to and stabilizing transcripts encoding core clock components such as CLOCK, thereby enhancing the amplitude and robustness of circadian oscillations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond stress adaptation and circadian regulation, CIRBP impacts critical cellular processes including DNA repair and telomerase activity. It interacts with components of the DNA damage response and the telomerase complex—binding to TERT mRNAs as well as the telomerase RNA component—to promote cell cycle progression and bypass replicative senescence."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pathological settings, extracellular CIRBP has been implicated in triggering harmful inflammatory cascades that lead to organ dysfunction. For instance, in sepsis, ischemia–reperfusion injury, traumatic insults, and even alcohol‐induced neuroinflammation, CIRBP promotes the release of proinflammatory mediators, facilitates the induction of cell death pathways (such as NETosis), and disrupts endothelial homeostasis, thereby contributing to tissue injury and poor clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": " Furthermore, in bladder cancer cells, CIRBP enhances oncogenic potential by binding to the 3′‑UTR of HIF‑1α mRNA to stabilize its expression, thereby promoting tumor proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Notably, circulating microRNAs such as miR‑130b‑3p can antagonize extracellular CIRBP activity and mitigate its inflammatory effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings reveal that CIRBP functions as a pivotal mediator linking environmental stress signals to innate immune activation, gene expression modulation, and cell survival. Its diverse roles—ranging from regulation of circadian rhythms and DNA repair to elicitation of proinflammatory responses and promotion of tumorigenesis—underscore the therapeutic potential of targeting CIRBP in conditions such as sepsis, ischemic injury, cancer, and neuroinflammatory disorders"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "–."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoling Qiang, Weng-Lang Yang, Rongqian Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3368"}], "href": "https://doi.org/10.1038/nm.3368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24097189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24097189"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Naomi-Liza Denning, Monowar Aziz, Atsushi Murao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.134172"}], "href": "https://doi.org/10.1172/jci.insight.134172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32027618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32027618"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weng-Lang Yang, Archna Sharma, Zhimin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3 inflammasome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep26571"}], "href": "https://doi.org/10.1038/srep26571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27217302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27217302"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sven Wellmann, Christoph Bührer, Eva Moderegger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01026"}], "href": "https://doi.org/10.1242/jcs.01026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15075239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15075239"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Frederic De Leeuw, Tong Zhang, Corinne Wauquier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2007.09.017"}], "href": "https://doi.org/10.1016/j.yexcr.2007.09.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17967451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17967451"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Toshiharu Sakurai, Katsuhiko Itoh, Hiroaki Higashitsuji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2006.02.007"}], "href": "https://doi.org/10.1016/j.bbamcr.2006.02.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16569452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16569452"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jörg Morf, Guillaume Rey, Kim Schneider, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1217726"}], "href": "https://doi.org/10.1126/science.1217726"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22923437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22923437"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ana Artero-Castro, Francisco B Callejas, Josep Castellvi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01386-08"}], "href": "https://doi.org/10.1128/MCB.01386-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19158277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19158277"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Youwei Zhang, Yangxiu Wu, Pingsu Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv1465"}], "href": "https://doi.org/10.1093/nar/gkv1465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26673712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26673712"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jung-Kuei Chen, Wen-Ling Lin, Zhang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1713912115"}], "href": "https://doi.org/10.1073/pnas.1713912115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29432179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29432179"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yasumasa Ode, Monowar Aziz, Hui Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding Protein Induces Neutrophil Extracellular Traps in the Lungs during Sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-42762-1"}], "href": "https://doi.org/10.1038/s41598-019-42762-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31000768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31000768"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alexandra C Bolognese, Archna Sharma, Weng-Lang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cmi.2016.43"}], "href": "https://doi.org/10.1038/cmi.2016.43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27569563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27569563"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Salil R Rajayer, Asha Jacob, Weng-Lang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein is an important mediator of alcohol-induced brain inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0079430"}], "href": "https://doi.org/10.1371/journal.pone.0079430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24223948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24223948"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhigang Li, Erica K Fan, Jinghua Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2017.187"}], "href": "https://doi.org/10.1038/cddis.2017.187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28492546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28492546"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mengxin Lu, Qiangqiang Ge, Gang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-1109-5"}], "href": "https://doi.org/10.1038/s41419-018-1109-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30315244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30315244"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Steven D Gurien, Monowar Aziz, Hui Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular microRNA 130b-3p inhibits eCIRP-induced inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201948075"}], "href": "https://doi.org/10.15252/embr.201948075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31724825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31724825"}]}]}]}
Synonyms	CIRP
Proteins	CIRBP_HUMAN
NCBI Gene ID	1153
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CIRBP has 10,907 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for CIRBP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CIRBP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CIRBP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CIRBP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CIRBP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CIRBP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CIRBP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CIRBP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CIRBP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CIRBP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CIRBP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CIRBP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CIRBP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CIRBP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CIRBP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CIRBP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CIRBP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CIRBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CIRBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CIRBP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CIRBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CIRBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CIRBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CIRBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CIRBP protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CIRBP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CIRBP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CIRBP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CIRBP gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CIRBP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CIRBP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CIRBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CIRBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CIRBP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CIRBP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CIRBP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CIRBP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CIRBP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CIRBP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CIRBP gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CIRBP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CIRBP from the GeneSigDB Published Gene Signatures dataset.