CITED1 Gene

Name	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
Description	This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CITED1 is emerging as a versatile transcriptional co‐regulator that, despite lacking a DNA‐binding domain, modulates cell fate decisions in development and disease. In the developing kidney, CITED1 is expressed in the cap mesenchyme of nephron progenitors, marking a self‐renewing, uninduced state prior to epithelial conversion; its dynamic regulation appears to help balance progenitor maintenance and timely differentiation, with loss or mis‐expression correlating with premature differentiation yet not necessarily disrupting nephrogenesis because of functional redundancy (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In the mammary gland, CITED1 is integrated into the estrogen receptor transcriptional network, where it contributes to the regulation of mature luminal differentiation and is co‐upregulated with other factors, such as EGR2, in ErbB2‐driven tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In neuronal contexts, CITED1 partners with TOX3 to influence cytoprotective transcriptional programs that tip the balance toward anti‐apoptotic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In adipose tissue, its expression serves as a marker of beige adipocytes and thermogenic capacity, with altered CITED1 levels correlating with shifts in the white–beige adipocyte program that have metabolic consequences."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Finally, oncogenic settings such as melanoma and papillary thyroid carcinoma exhibit up‐regulation of CITED1 that is linked to activated MAPK signaling cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these studies underscore that CITED1 functions as a multifaceted co‐regulator—integrating signals in stem cell maintenance, differentiation, and oncogenic transformation across diverse tissues.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jennifer L Fetting, Justin A Guay, Michele J Karolak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.089078"}], "href": "https://doi.org/10.1242/dev.089078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24284212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24284212"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Scott Boyle, Toshi Shioda, Alan O Perantoni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.21242"}], "href": "https://doi.org/10.1002/dvdy.21242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17615577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17615577"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sylvia A Hilliard, Xiao Yao, Samir S El-Dahr "}, {"type": "b", "children": [{"type": "t", "text": "Mdm2 is required for maintenance of the nephrogenic niche."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2014.01.009"}], "href": "https://doi.org/10.1016/j.ydbio.2014.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24440154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24440154"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maaike P A van Bragt, Xin Hu, Ying Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.03881"}], "href": "https://doi.org/10.7554/eLife.03881"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25415051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25415051"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rachelle L Dillon, Stephen T Brown, Chen Ling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00866-07"}], "href": "https://doi.org/10.1128/MCB.00866-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17938205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17938205"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sonja Dittmer, Zsuzsa Kovacs, Shauna H Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.068759"}], "href": "https://doi.org/10.1242/jcs.068759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21172805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21172805"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Andrew L Carey, Camilla Vorlander, Medini Reddy-Luthmoodoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced UCP-1 content in in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0091997"}], "href": "https://doi.org/10.1371/journal.pone.0091997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24642703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24642703"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Antoine Reginensi, Leonie Enderle, Alex Gregorieff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A critical role for NF2 and the Hippo pathway in branching morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12309"}], "href": "https://doi.org/10.1038/ncomms12309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27480037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27480037"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Evangelos Kiskinis, Lemonia Chatzeli, Edward Curry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIP140 represses the \"brown-in-white\" adipocyte program including a futile cycle of triacylglycerol breakdown and synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2013-1254"}], "href": "https://doi.org/10.1210/me.2013-1254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24479876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24479876"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Aaron G Smith, Wen Lim, Michael Pearen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pigment Cell Melanoma Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1755-148X.2011.00843.x"}], "href": "https://doi.org/10.1111/j.1755-148X.2011.00843.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21362156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21362156"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Reiko Watanabe, Yoshitaka Hayashi, Miho Sassa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1507/endocrj.k08e-329"}], "href": "https://doi.org/10.1507/endocrj.k08e-329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19194051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19194051"}]}]}]}
Synonyms	MSG1
Proteins	CITE1_HUMAN
NCBI Gene ID	4435
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CITED1 has 4,841 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 106 datasets.

Click the + buttons to view associations for CITED1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CITED1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CITED1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CITED1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CITED1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CITED1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CITED1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CITED1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CITED1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CITED1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CITED1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CITED1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CITED1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CITED1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CITED1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CITED1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CITED1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CITED1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CITED1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CITED1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CITED1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CITED1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CITED1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CITED1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CITED1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CITED1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CITED1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CITED1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CITED1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CITED1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CITED1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CITED1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CITED1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CITED1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CITED1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CITED1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CITED1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CITED1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CITED1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CITED1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of CITED1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of CITED1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.