CLASP2 Gene

Name	cytoplasmic linker associated protein 2
Description	Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; focal adhesion; and microtubule cytoskeleton. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CLASP2 is emerging as a multifunctional microtubule‐associated protein whose dynamic regulation is essential for numerous cellular processes. In many cell types, CLASP2 modulates microtubule behavior by suppressing catastrophe and promoting rescue, and by switching between plus‐end tracking and lateral lattice binding in a phosphorylation‐dependent manner. For example, in migrating epithelial cells, partially phosphorylated CLASP2—regulated by glycogen synthase kinase‑3β (GSK3β)—tracks microtubule plus ends in the cell body while decorating the microtubule lattice in the leading edge lamella, thereby guiding directional microtubule extension (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the cell periphery, CLASP2 is recruited to focal adhesions—often in complex with LL5β and other scaffold proteins—to promote microtubule tethering and facilitate focal adhesion turnover, a process key to efficient cell migration (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, its association with Golgi‐derived microtubules appears to extend microtubule nucleation activity from the centrosome to the Golgi apparatus, thereby coordinating vesicular trafficking and organelle function (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In dividing cells, CLASP2 contributes to the assembly and stabilization of the mitotic spindle. Loss of CLASP2 disrupts kinetochore–microtubule attachments and causes spindle defects and chromosome missegregation, indicating that it plays an important role in ensuring proper chromosome congression and mitotic fidelity (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the nervous system, CLASP2 is crucial for neuronal morphogenesis. It regulates axon and dendrite outgrowth and influences synaptic organization by mediating microtubule stabilization. In cultured neurons and developing brain tissue, altered CLASP2 levels affect neuronal polarity and synapse formation, including at neuromuscular junctions where it is essential for proper acetylcholine receptor insertion (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, studies in metabolic tissues indicate that CLASP2 participates in insulin‐stimulated cytoskeletal reorganization through its association with proteins such as MARK2, linking microtubule dynamics to metabolic signaling (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " The relevance of CLASP2 regulation is further underscored by its recurrent mutation in adrenocortical oncocytomas, suggesting a potential link to disease (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight that through post‐translational modifications and interactions with key partners, CLASP2 functions as a central hub bridging microtubule dynamics to processes such as focal adhesion turnover, directed migration, mitotic spindle assembly, and neuronal network formation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Thus, CLASP2 stands out as a versatile regulator essential for maintaining proper microtubule architecture and translating extracellular cues into coordinated intracellular responses.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Torsten Wittmann, Clare M Waterman-Storer "}, {"type": "b", "children": [{"type": "t", "text": "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200412114"}], "href": "https://doi.org/10.1083/jcb.200412114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15955847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15955847"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Praveen Kumar, Karen S Lyle, Sarah Gierke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GSK3beta phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200901042"}], "href": "https://doi.org/10.1083/jcb.200901042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19289791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19289791"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Praveen Kumar, Michael S Chimenti, Hayley Pemble, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.316661"}], "href": "https://doi.org/10.1074/jbc.M111.316661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22467876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22467876"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Samantha J Stehbens, Matthew Paszek, Hayley Pemble, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2975"}], "href": "https://doi.org/10.1038/ncb2975"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24859005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24859005"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Boon Cheng Lim, Shinji Matsumoto, Hideki Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.185439"}], "href": "https://doi.org/10.1242/jcs.185439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27378169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27378169"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sabrina Rivero, Jesus Cardenas, Michel Bornens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2009.47"}], "href": "https://doi.org/10.1038/emboj.2009.47"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19242490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19242490"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Stefano Maffini, Ana R R Maia, Amity L Manning, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2009.07.059"}], "href": "https://doi.org/10.1016/j.cub.2009.07.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19733075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19733075"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yuko Mimori-Kiyosue, Ilya Grigoriev, Hiroyuki Sasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2006.00990.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2006.00990.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16866869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16866869"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Uwe Beffert, Gregory M Dillon, Josefa M Sullivan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2108-12.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.2108-12.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23035100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23035100"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gregory M Dillon, William A Tyler, Kerilyn C Omuro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2017.02.039"}], "href": "https://doi.org/10.1016/j.neuron.2017.02.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28285824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28285824"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nadine Schmidt, Sreya Basu, Stefan Sladecek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201111130"}], "href": "https://doi.org/10.1083/jcb.201111130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22851317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22851317"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rikke Kruse, James Krantz, Natalie Barker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.RA117.000011"}], "href": "https://doi.org/10.1074/mcp.RA117.000011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28550165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28550165"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yanan Cao, Minghui He, Zhibo Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1249480"}], "href": "https://doi.org/10.1126/science.1249480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24700472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24700472"}]}]}]}
Proteins	CLAP2_HUMAN
NCBI Gene ID	23122
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CLASP2 has 7,622 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 120 datasets.

Click the + buttons to view associations for CLASP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CLASP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CLASP2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CLASP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CLASP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CLASP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CLASP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CLASP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CLASP2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CLASP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CLASP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CLASP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CLASP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CLASP2 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CLASP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CLASP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CLASP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CLASP2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CLASP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CLASP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CLASP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CLASP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CLASP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CLASP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CLASP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with CLASP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CLASP2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CLASP2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CLASP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CLASP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CLASP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CLASP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CLASP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CLASP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CLASP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CLASP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CLASP2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CLASP2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CLASP2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CLASP2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CLASP2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CLASP2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.