CLCN3 Gene

HGNC Family	Ion channels
Name	chloride channel, voltage-sensitive 3
Description	This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CLCN3, a member of the CLC chloride channel family, has emerged as a multifunctional protein that mediates diverse cellular processes. Several independent studies have demonstrated that CLCN3 plays a critical role in the acidification of intracellular vesicles by serving as an anion “shunt” that facilitates the H⁺ pump–driven luminal acidification in endosomes; indeed, isoform‐specific roles have been uncovered with ClC‐3A localizing to late endosomes and ClC‐3B targeting the Golgi apparatus (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In murine models, loss of CLCN3 function leads to defective vesicular acidification and consequent neurodegeneration, implicating its importance in neuronal protein degradation and synaptic homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, CLCN3 contributes to cell volume regulation; studies in HeLa cells and vascular smooth muscle cells show that suppression of CLCN3 expression ablates volume‐sensitive Cl⁻ currents and compromises regulatory volume decrease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In the immune system, CLCN3 is expressed in polymorphonuclear leukocytes where it supports NADPH oxidase activity, phagocytosis, and effective cell migration—functions essential for host defense."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cancer, particularly in gliomas, increased expression and plasma membrane localization of CLCN3 are correlated with robust outwardly rectifying Cl⁻ currents that facilitate dynamic cell shape changes and invasive behavior. In glioma cells, CaMKII‐dependent phosphorylation regulates CLCN3 activity, and its inhibition strongly reduces cell invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, RNA interference screening has identified CLCN3 as a modulator of apoptotic signaling, with targeted silencing altering TRAIL-induced caspase-3 activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In the context of cellular differentiation, CLCN3 has been shown to be a direct target of microRNA regulation during myogenesis; sustained expression of CLCN3 impairs skeletal muscle differentiation by promoting proliferation and inhibiting the differentiation program."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, CLCN3 may participate in the transmembrane flux of reactive oxygen species in endothelial cells, where its activity facilitates the entry of extracellular superoxide, triggering intracellular Ca²⁺ signaling and subsequent mitochondrial responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Finally, evidence from studies of synaptic vesicle biogenesis indicates that CLCN3 is sorted into synaptic vesicles in an adaptor protein 3 (AP-3)–dependent manner, where it co-segregates with zinc transporters to regulate vesicular ion composition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore that CLCN3 is a key regulator of intracellular pH, cell volume, vesicular trafficking, apoptotic signaling, and migratory behavior across multiple cell types. Its multifaceted roles in endosomal acidification, immune cell function, and cancer cell invasion, as well as its regulation during muscle differentiation, highlight its potential as a therapeutic target in several human disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mariko Hara-Chikuma, Baoxue Yang, N D Sonawane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M407030200"}], "href": "https://doi.org/10.1074/jbc.M407030200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15504734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15504734"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Martina Gentzsch, Liying Cui, April Mengos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M211050200"}], "href": "https://doi.org/10.1074/jbc.M211050200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12471024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12471024"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Linda W Dickerson, Daniel J Bonthius, Brian C Schutte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-8993(02)03519-9"}], "href": "https://doi.org/10.1016/s0006-8993(02"}, {"type": "t", "text": "03519-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12470859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12470859"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Momono Yoshikawa, Shinichi Uchida, Junji Ezaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1365-2443.2002.00539.x"}], "href": "https://doi.org/10.1046/j.1365-2443.2002.00539.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12059962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12059962"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gerrit J Poelarends, Wil N Konings "}, {"type": "b", "children": [{"type": "t", "text": "The transmembrane domains of the ABC multidrug transporter LmrA form a cytoplasmic exposed, aqueous chamber within the membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206508200"}], "href": "https://doi.org/10.1074/jbc.M206508200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12183459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12183459"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jia-Guo Zhou, Jing-Li Ren, Qin-Ying Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of intracellular Cl- concentration through volume-regulated ClC-3 chloride channels in A10 vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M412813200"}], "href": "https://doi.org/10.1074/jbc.M412813200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15596438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15596438"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jessica G Moreland, A Paige Davis, Gail Bailey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M511030200"}], "href": "https://doi.org/10.1074/jbc.M511030200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16522634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16522634"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "M L Olsen, S Schade, S A Lyons, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of voltage-gated chloride channels in human glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12843258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12843258"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Vishnu Anand Cuddapah, Harald Sontheimer "}, {"type": "b", "children": [{"type": "t", "text": "Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.097675"}], "href": "https://doi.org/10.1074/jbc.M109.097675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20139089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20139089"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Vincent Chi Hang Lui, Steven Sin Sai Lung, Jenny Kan Suen Pu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Invasion of human glioma cells is regulated by multiple chloride channels including ClC-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21115901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21115901"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dmitriy Ovcharenko, Kevin Kelnar, Charles Johnson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-1484"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-1484"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18006822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18006822"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Katarzyna Goljanek-Whysall, Helio Pais, Tina Rathjen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.101758"}], "href": "https://doi.org/10.1242/jcs.101758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22595520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22595520"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Brian J Hawkins, Muniswamy Madesh, C J Kirkpatrick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e06-09-0830"}], "href": "https://doi.org/10.1091/mbc.e06-09-0830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17360969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17360969"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Gloria Salazar, Rachal Love, Melanie L Styers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402331200"}], "href": "https://doi.org/10.1074/jbc.M402331200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15073168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15073168"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jiao Zhang, Yau-Chi Chan, Jenny Chung-Yee Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00326.2011"}], "href": "https://doi.org/10.1152/ajpcell.00326.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22357737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22357737"}]}]}]}
Synonyms	CLC3, CLC-3
Proteins	CLCN3_HUMAN
NCBI Gene ID	1182
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CLCN3 has 8,327 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for CLCN3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CLCN3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CLCN3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CLCN3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CLCN3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CLCN3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CLCN3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CLCN3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CLCN3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CLCN3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CLCN3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CLCN3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CLCN3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CLCN3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CLCN3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CLCN3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CLCN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CLCN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CLCN3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CLCN3 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CLCN3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CLCN3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CLCN3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CLCN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CLCN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CLCN3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CLCN3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CLCN3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CLCN3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CLCN3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CLCN3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CLCN3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CLCN3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CLCN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CLCN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CLCN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CLCN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CLCN3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CLCN3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CLCN3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CLCN3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CLCN3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.