| HGNC Family | C-type lectin domain family (CLEC) |
| Name | C-type lectin domain family 19, member A |
| Description | Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Genome‐wide association studies have implicated the C‐type lectin CLEC19A as a candidate gene involved in distinct biological processes underlying both periodontal disease phenotypes and smoking behavior. In periodontal research, CLEC19A was identified in a complex trait (PCT1) characterized by a uniformly high pathogen load, and its genetic variation has been linked to clinical periodontal measures such as edentulism and increased pocket depth, suggesting a potential role in modulating immune responses and epithelial barrier functions in the oral cavity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, independent genome‐wide analyses in smoking behavior revealed significant associations between SNPs in the vicinity of CLEC19A and smoking quantity—a finding that, given the gene’s proximity to loci implicated in attention‐deficit hyperactivity disorder, hints at broader neurobehavioral or neuroimmune links."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these data suggest that CLEC19A may contribute to the regulation of inflammatory and barrier mechanisms in the periodontium and potentially mediate interrelated pathways affecting smoking-related and neuropsychiatric traits. Future mechanistic studies are required to clarify its precise functional roles and to evaluate its potential as a biomarker or therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Steven Offenbacher, Kimon Divaris, Silvana P Barros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddw069"}], "href": "https://doi.org/10.1093/hmg/ddw069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26962152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26962152"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Teresa Yang, Bin Cheng, James M Noble, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication of gene polymorphisms associated with periodontitis-related traits in an elderly cohort: the Washington Heights/Inwood Community Aging Project Ancillary Study of Oral Health."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Periodontol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcpe.13605"}], "href": "https://doi.org/10.1111/jcpe.13605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35179257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35179257"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A Loukola, J Wedenoja, K Keskitalo-Vuokko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2013.72"}], "href": "https://doi.org/10.1038/mp.2013.72"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23752247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23752247"}]}]}]}
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| Proteins | CL19A_HUMAN |
| NCBI Gene ID | 728276 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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CLEC19A has 404 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 26 datasets.
Click the + buttons to view associations for CLEC19A from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CLEC19A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of CLEC19A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of CLEC19A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing CLEC19A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with CLEC19A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with CLEC19A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of CLEC19A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with CLEC19A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CLEC19A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with CLEC19A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing CLEC19A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of CLEC19A gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of CLEC19A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of CLEC19A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with CLEC19A gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with CLEC19A gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with CLEC19A gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with CLEC19A gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of CLEC19A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of CLEC19A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of CLEC19A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of CLEC19A gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CLEC19A gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CLEC19A gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with CLEC19A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with CLEC19A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
