{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the studies presented directly address the role of CNBD2, the diverse findings across these investigations provide a framework from which one may infer its potential functions. CNBD2 encodes a protein harboring a cyclic nucleotide‐binding domain, suggesting that it participates in the transduction of intracellular signals via cyclic AMP or cyclic GMP. In related contexts, molecules operating in similar pathways have been implicated in the regulation of gene expression and long noncoding RNA function"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", modulation of inflammatory and cell‐adhesion processes in autoimmunity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and the control of hemostatic factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, studies employing spliceosomal RNA repair"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "and investigations into host responses during persistent viral infections"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "emphasize the importance of precise RNA–protein interactions in maintaining cellular homeostasis. Other research highlights the contribution of noncoding RNAs in aging"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", deregulated gene expression in cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and the identification of tissue‐specific molecules for male fertility control"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", as well as genetic associations with metabolic syndrome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In light of these findings, it is plausible that CNBD2 serves as a multifaceted modulator of key signaling cascades that regulate a variety of physiological processes including gene transcription, splicing fidelity, immune defense, and metabolic regulation. Further targeted studies are needed to elucidate its specific mechanisms and potential as a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Florian Kopp, Mahmoud M Elguindy, Mehmet E Yalvac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PUMILIO hyperactivity drives premature aging of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Norad"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.42650"}], "href": "https://doi.org/10.7554/eLife.42650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30735131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30735131"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dan Vodo, Ofer Sarig, Shamir Geller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006008"}], "href": "https://doi.org/10.1371/journal.pgen.1006008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27148741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27148741"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "James S Pankow, Weihong Tang, Nathan Pankratz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.116.308109"}], "href": "https://doi.org/10.1161/ATVBAHA.116.308109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28082259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28082259"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Malgorzata Ewa Rogalska, Mojca Tajnik, Danilo Licastro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic activity of modified U1 core spliceosomal particles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11168"}], "href": "https://doi.org/10.1038/ncomms11168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27041075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27041075"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lingling Han, Xiu Xin, Hailong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular response to persistent foot-and-mouth disease virus infection is linked to specific types of alterations in the host cell transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-23478-0"}], "href": "https://doi.org/10.1038/s41598-018-23478-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29568077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29568077"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nicole Noren Hooten, Michele K Evans "}, {"type": "b", "children": [{"type": "t", "text": "Age and poverty status alter the coding and noncoding transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.101823"}], "href": "https://doi.org/10.18632/aging.101823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30779705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30779705"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Suthipong Chujan, Tawit Suriyo, Teerapat Ungtrakul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential candidate treatment agents for targeting of cholangiocarcinoma identified by gene expression profile analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/br.2018.1101"}], "href": "https://doi.org/10.3892/br.2018.1101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29930804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29930804"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Katarzyna Kent, Madelaine Johnston, Natasha Strump, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2020.00061"}], "href": "https://doi.org/10.3389/fcell.2020.00061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32161754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32161754"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sahar Elouej, Insaf Rejeb, Redha Attaoua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gender-specific associations of genetic variants with metabolic syndrome components in the Tunisian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/07435800.2016.1141945"}], "href": "https://doi.org/10.3109/07435800.2016.1141945"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26905813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26905813"}]}]}]}