COL14A1 Gene

HGNC Family	Collagens (COL), Fibronectin type III domain containing
Name	collagen, type XIV, alpha 1
Description	This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Type XIV collagen, encoded by the COL14A1 gene, is a fibril‐associated collagen with interrupted triple‐helical domains that plays a key regulatory role in extracellular matrix formation and tissue biomechanics. In developing tendons, for example, COL14A1 is one of several tendon‐associated collagens induced by early growth response transcription factors to promote proper fibrillogenesis and collagen fibril assembly, thereby contributing to the formation and strength of the tendon extracellular matrix (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition to its role in tendon development, alterations in COL14A1 expression have been implicated in early collagen fibril regulation in other tissues; for instance, increased COL14A1 expression in the intima–media of pulmonary arteries is associated with extracellular matrix remodeling and altered vessel mechanics (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the heart and cornea, studies in COL14A1‐deficient animal models reveal that loss of this collagen results in disrupted collagen network architecture, premature fibril growth or irregular fibril diameters, and ultimately impaired tissue stiffness and function. These findings underscore its importance for proper cardiac interstitium formation and corneal stromal integrity during development as well as in wound healing (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, alterations in COL14A1 have been explored in disease‐related contexts. Epigenetic profiling in high‐grade soft tissue sarcomas identified differential methylation at the COL14A1 locus as part of a panel of genes that may serve as biomarkers for tumor classification (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In parallel, studies in dental pulp stem cells indicate that COL14A1 expression is modulated during extracellular matrix remodeling associated with odontogenic differentiation, reinforcing its general role in regulating tissue‐specific matrix deposition (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic studies in certain inherited cutaneous disorders have raised the possibility that mutations in COL14A1 might contribute to pathology, although such findings require further evaluation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these studies support a multifaceted role for COL14A1 in orchestrating extracellular matrix assembly, modulating collagen fibril growth in a tissue‐specific manner, and influencing the biomechanical properties of diverse connective tissues.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Véronique Lejard, Frédéric Blais, Marie-Justine Guerquin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EGR1 and EGR2 involvement in vertebrate tendon differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.153106"}], "href": "https://doi.org/10.1074/jbc.M110.153106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21173153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21173153"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Heather L Ansorge, Xianmin Meng, Guiyun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M805582200"}], "href": "https://doi.org/10.1074/jbc.M805582200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19136672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19136672"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Julia Hoffmann, Leigh M Marsh, Mario Pieper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00383.2014"}], "href": "https://doi.org/10.1152/ajplung.00383.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25840998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25840998"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ge Tao, Agata K Levay, Jacqueline D Peacock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Collagen XIV is important for growth and structural integrity of the myocardium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2012.08.002"}], "href": "https://doi.org/10.1016/j.yjmcc.2012.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22906538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22906538"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mei Sun, Nabeel Zafrullah, Sheila Adams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Collagen XIV Is an Intrinsic Regulator of Corneal Stromal Structure and Function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2021.08.016"}], "href": "https://doi.org/10.1016/j.ajpath.2021.08.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34560063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34560063"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marcus Renner, Thomas Wolf, Hannah Meyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/gb-2013-14-12-r137"}], "href": "https://doi.org/10.1186/gb-2013-14-12-r137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24345474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24345474"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "He Wang, Tingting Ning, Ci Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27954"}], "href": "https://doi.org/10.1002/jcp.27954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30556904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30556904"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Bi-Rong Guo, Xin Zhang, Gang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing identifies a COL14A1 mutation in a large Chinese pedigree with punctate palmoplantar keratoderma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2012-100868"}], "href": "https://doi.org/10.1136/jmedgenet-2012-100868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22972947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22972947"}]}]}]}
Synonyms	UND
Proteins	COEA1_HUMAN
NCBI Gene ID	7373
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

COL14A1 has 8,210 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for COL14A1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

COL14A1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by COL14A1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of COL14A1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of COL14A1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of COL14A1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of COL14A1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of COL14A1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of COL14A1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of COL14A1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of COL14A1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of COL14A1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of COL14A1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of COL14A1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of COL14A1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with COL14A1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with COL14A1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with COL14A1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of COL14A1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of COL14A1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of COL14A1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of COL14A1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing COL14A1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing COL14A1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing COL14A1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with COL14A1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with COL14A1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of COL14A1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with COL14A1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with COL14A1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with COL14A1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with COL14A1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of COL14A1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by COL14A1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with COL14A1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with COL14A1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with COL14A1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with COL14A1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with COL14A1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at COL14A1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of COL14A1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of COL14A1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.