COPE Gene

Name	coatomer protein complex, subunit epsilon
Description	The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The coat protein complex I (COPI) is a highly conserved, multi‐subunit machinery that orchestrates retrograde vesicle trafficking between the Golgi apparatus and the endoplasmic reticulum as well as intra‐Golgi transport. Recent studies indicate that COPI not only mediates conventional membrane recycling but also functions in specialized processes such as the regulation of lipid droplet morphology and the budding of nanolipid droplets that facilitate targeted delivery of enzymes for triacylglycerol synthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, COPI‐mediated retrograde transport is critical for the routing of activated receptors—for example, the epidermal growth factor receptor—to the endoplasmic reticulum and then the nucleus, thereby linking vesicular trafficking with cellular signal transduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Structural analyses at near–atomic resolution have delineated the architecture of the COPI coat, revealing that the small GTPase Arf1 engages multiple COPI subunits—including β, γ, δ, ε, and ζ—with distinct binding interfaces that facilitate coat assembly and disassembly."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Functional studies demonstrate that regulatory factors such as Arf GTPase–activating proteins, ubiquitin ligases like PIRH2 (which targets ε‐COP), and scaffolding proteins including Scyl1 and GORAB modulate COPI vesicle formation, cargo sorting, and maintenance of Golgi morphology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, alterations in individual COPI subunits are increasingly linked to pathological conditions; for instance, overexpression of COPB2 correlates with enhanced cell proliferation and invasion in breast and colon cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while mutations affecting ε‐COP and related subunits impair endoplasmic reticulum–Golgi trafficking, resulting in defects in receptor recycling and overall organelle homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": " In plants, disruption of COPI function similarly perturbs Golgi structure and is associated with compromised pollen acceptance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, reviews of post‐translational modifications indicate that dynamic regulation of COPI activity is central to adapting vesicular trafficking to varying metabolic and stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Together, these findings underscore that COPI is a central mediator of intracellular membrane traffic whose dynamic assembly, regulation, and subunit interactions are vital for maintaining organelle homeostasis, proper cargo sorting, and signal propagation in both normal physiology and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Florian Wilfling, Abdou Rachid Thiam, Maria-Jesus Olarte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.01607"}], "href": "https://doi.org/10.7554/eLife.01607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24497546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24497546"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying-Nai Wang, Hongmei Wang, Hirohito Yamaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.07.096"}], "href": "https://doi.org/10.1016/j.bbrc.2010.07.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20674546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20674546"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Svetlana O Dodonova, Patrick Aderhold, Juergen Kopp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.26691"}], "href": "https://doi.org/10.7554/eLife.26691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28621666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28621666"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Peter J Watson, Gabriella Frigerio, Brett M Collins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gamma-COP appendage domain - structure and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2004.00158.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2004.00158.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14690497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14690497"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhe Sun, Frank Anderl, Kathrin Fröhlich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2007.00554.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2007.00554.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17451557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17451557"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Carolin Weimer, Rainer Beck, Priska Eckert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200806140"}], "href": "https://doi.org/10.1083/jcb.200806140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19015319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19015319"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jonathon L Burman, Jason N R Hamlin, Peter S McPherson "}, {"type": "b", "children": [{"type": "t", "text": "Scyl1 regulates Golgi morphology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0009537"}], "href": "https://doi.org/10.1371/journal.pone.0009537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20209057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20209057"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Satoru Maruyama, Naoto Miyajima, Miyuki Bohgaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-007-9586-3"}], "href": "https://doi.org/10.1007/s11010-007-9586-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17721809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17721809"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tomasz M Witkos, Wing Lee Chan, Merja Joensuu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-08044-6"}], "href": "https://doi.org/10.1038/s41467-018-08044-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30631079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30631079"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Adheesh Bhandari, Chen Zheng, Namita Sindan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COPB2 is up-regulated in breast cancer and plays a vital role in the metastasis via N-cadherin and Vimentin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14398"}], "href": "https://doi.org/10.1111/jcmm.14398"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31119859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31119859"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yan Wang, Zhi Chai, Min Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COPB2 suppresses cell proliferation and induces cell cycle arrest in human colon cancer by regulating cell cycle-related proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2017.5506"}], "href": "https://doi.org/10.3892/etm.2017.5506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29399086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29399086"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Q Guo, E Vasile, M Krieger "}, {"type": "b", "children": [{"type": "t", "text": "Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (1994)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.125.6.1213"}], "href": "https://doi.org/10.1083/jcb.125.6.1213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "8207054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/8207054"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Peng Xu, Hannah M Hankins, Chris MacDonald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.28342"}], "href": "https://doi.org/10.7554/eLife.28342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29058666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29058666"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "L Hobbie, A S Fisher, S Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isolation of three classes of conditional lethal Chinese hamster ovary cell mutants with temperature-dependent defects in low density lipoprotein receptor stability and intracellular membrane transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (1994)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "8063714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/8063714"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Daniel A Cabada Gomez, M Isabella Chavez, Alejandra N Cobos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COPI complex isoforms are required for the early acceptance of compatible pollen grains in Arabidopsis thaliana."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Plant Reprod (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00497-020-00387-9"}], "href": "https://doi.org/10.1007/s00497-020-00387-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32277349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32277349"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Peter M Luo, Michael Boyce "}, {"type": "b", "children": [{"type": "t", "text": "Directing Traffic: Regulation of COPI Transport by Post-translational Modifications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2019.00190"}], "href": "https://doi.org/10.3389/fcell.2019.00190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31572722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31572722"}]}]}]}
Synonyms	EPSILON-COP
Proteins	COPE_HUMAN
NCBI Gene ID	11316
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

COPE has 8,140 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 112 datasets.

Click the + buttons to view associations for COPE from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

COPE Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by COPE gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of COPE gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of COPE gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of COPE gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of COPE gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of COPE gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of COPE gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of COPE gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of COPE gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of COPE gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of COPE gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of COPE gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of COPE gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with COPE protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with COPE gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of COPE gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of COPE gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of COPE gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of COPE gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing COPE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing COPE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing COPE protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing COPE protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with COPE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with COPE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of COPE gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with COPE gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with COPE gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with COPE gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of COPE protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with COPE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with COPE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with COPE gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with COPE gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at COPE gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of COPE gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of COPE gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing COPE from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of COPE gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with COPE gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.