CRCP Gene

Name	CGRP receptor component
Description	This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Calcitonin gene‐related peptide receptor component protein (CRCP) is emerging as a multifunctional adaptor that is essential for the proper signaling of the CGRP receptor. In several studies, CRCP has been shown to be a required intracellular partner that couples the G protein‐coupled receptor complex—composed of the calcitonin–like receptor (CLR) and RAMP1—to downstream signal transduction cascades."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " For example, interaction studies reveal that CRCP directly binds to an intracellular domain of CLR, a step that is necessary for receptor activation and CGRP‑mediated responses in various cell types such as keratinocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its classical role in CGRP receptor signaling, CRCP has been identified as the genuine mammalian orthologue of a conserved yeast RNA polymerase III subunit (C17), suggesting a dual function that spans from transcriptional regulation to neuroendocrine signal transduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " This multifunctional nature is further highlighted by studies in reproductive tissues where CRCP is highly expressed in the head region of mature spermatozoa, implying a role in the acrosome reaction and thus in fertility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", as well as in the myometrium where elevated CRCP mRNA levels in gravid tissue suggest involvement in myometrial contractility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n CRCP also appears to modulate immune and neuroprotective functions. In experimental autoimmune encephalomyelitis (EAE), for instance, the cell‐specific intracellular translocation of CRCP correlates with CGRP’s ability to inhibit microglial activation, supporting a protective role in central nervous system inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in vascular smooth muscle cells, CRCP has been implicated in the regulation of static pressure–induced proliferation by modulating caveolin‑1/ERK1/2 signaling pathways; gene silencing of CRCP enhances proliferation and p‐ERK1/2 expression in response to mechanical stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, differential expression profiling in colorectal carcinoma subtypes has revealed that CRCP is expressed at higher levels in serrated adenocarcinoma than in high‐microsatellite instability tumors, suggesting that CRCP may also contribute to modulating the tumor microenvironment and immune responses in certain cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Alterations in CRCP distribution have further been observed in models of chemotherapy‐induced neurotoxicity, consistent with changes in meningeal sensory function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, CRCP functions as a crucial intracellular adaptor for the CGRP receptor complex, ensuring effective receptor signaling in diverse tissues. Its roles extend beyond neurovascular coupling to include regulation of transcription (as a homolog of a Pol III subunit), modulation of reproductive and contractile functions, and participation in immune as well as vascular smooth muscle responses. These multifaceted actions position CRCP as a key regulator at the intersection of neuroendocrine, inflammatory, and cellular proliferation pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Quanzhi Hou, Travis Barr, Lucy Gee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Keratinocyte expression of calcitonin gene-related peptide β: implications for neuropathic and inflammatory pain mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pain (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pain.2011.04.033"}], "href": "https://doi.org/10.1016/j.pain.2011.04.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21641113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21641113"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sophie C Egea, Ian M Dickerson "}, {"type": "b", "children": [{"type": "t", "text": "Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2011-1459"}], "href": "https://doi.org/10.1210/en.2011-1459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22315449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22315449"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Adviye A Tolun, Ian M Dickerson, Arun Malhotra "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression and purification of human calcitonin gene-related peptide-receptor component protein in Escherichia coli."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Expr Purif (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pep.2006.09.008"}], "href": "https://doi.org/10.1016/j.pep.2006.09.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17067815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17067815"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Magali Siaut, Cécile Zaros, Emilie Levivier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.1.195-205.2003"}], "href": "https://doi.org/10.1128/MCB.23.1.195-205.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12482973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12482973"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "W Balkan, E L Oates, G A Howard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (1999)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/endo.140.3.6541"}], "href": "https://doi.org/10.1210/endo.140.3.6541"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10067875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10067875"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nina Goharkhay, Jing Lu, Juan C Felix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Perinatol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-2007-986684"}], "href": "https://doi.org/10.1055/s-2007-986684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17853344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17853344"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Claudia Sardi, Laura Zambusi, Annamaria Finardi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of calcitonin gene-related peptide and receptor component protein in experimental autoimmune encephalomyelitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jneuroim.2014.03.008"}], "href": "https://doi.org/10.1016/j.jneuroim.2014.03.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24746422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24746422"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yan-Mei Liu, Hong-Yan Peng, Feng Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Involvement of the receptor component protein in the regulation of vascular peroxidase-1 expression induced by calcitonin gene-related peptide and angiotensin II in vascular smooth muscle cell]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sheng Li Xue Bao (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25896050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25896050"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Feng Guo, Li Yang, Jingfei Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of CGRP-RCP in the caveolin-1/ERK1/2 signal pathway in the static pressure-induced proliferation of vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26582"}], "href": "https://doi.org/10.1002/jcp.26582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29741760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29741760"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "José García-Solano, María Del Carmen Turpin-Sevilla, Francisco García-García, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differences in gene expression profiling and biomarkers between histological colorectal carcinoma subsets from the serrated pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/his.13889"}], "href": "https://doi.org/10.1111/his.13889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31025430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31025430"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Éva Deák, Judit Rosta, Krisztina Boros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic adriamycin treatment impairs CGRP-mediated functions of meningeal sensory nerves."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropeptides (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.npep.2018.04.003"}], "href": "https://doi.org/10.1016/j.npep.2018.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29661478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29661478"}]}]}]}
Synonyms	RCP9, RPC9, CGRPRCP, CGRP-RCP
Proteins	RPC9_HUMAN
NCBI Gene ID	27297
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CRCP has 5,446 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for CRCP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CRCP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CRCP gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CRCP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CRCP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CRCP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CRCP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CRCP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CRCP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CRCP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CRCP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CRCP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CRCP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CRCP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CRCP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CRCP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CRCP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CRCP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CRCP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of CRCP gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing CRCP protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CRCP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CRCP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CRCP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CRCP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CRCP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CRCP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CRCP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CRCP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CRCP gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CRCP gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CRCP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CRCP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CRCP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CRCP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CRCP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CRCP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CRCP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CRCP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CRCP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CRCP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CRCP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.