CRTC1 Gene

Name	CREB regulated transcription coactivator 1
Description	Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CREB‐regulated transcription coactivator 1 (CRTC1) is emerging as a pivotal modulator of CREB‐dependent gene expression that integrates extracellular signals with long‐lasting transcriptional programs in diverse tissues. In neurons, CRTC1 is maintained in the cytoplasm under basal conditions but rapidly translocates into the nucleus in response to synaptic stimulation and calcium influx, where it potently coactivates CREB to induce immediate‐early genes essential for synaptic plasticity and long‐term memory formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In line with its role in activity‐dependent gene regulation, Sirt1‐mediated deacetylation of CRTC1 enhances its activity and promotes neuroprotection, partly via upregulation of brain‐derived neurotrophic factor expression in models of neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Beyond the central nervous system, CRTC1 functions in the hypothalamus to couple hormonal signals to metabolic and reproductive outcomes; dephosphorylated CRTC1 stimulates the expression of neuropeptides such as CART and Kiss1, thereby mediating leptin’s effects on satiety and fertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, modifications that impair CREB’s interaction with CRTC1—for example, activity‐dependent glycosylation of CREB—can repress CREB-dependent transcription and impact neural development and memory consolidation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In sensory neurons, alterations in upstream signaling—such as loss of TRPV1 function—lead to nuclear exclusion of CRTC1, which in turn modulates downstream neuropeptide (e.g., CGRP) production, linking nociception to systemic metabolic health and even longevity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In pathological contexts, impaired CRTC1-dependent transcription has been implicated in neurodegenerative disorders such as Alzheimer’s disease, where reduced calcium influx and disrupted dephosphorylation hinder activity-induced gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, aberrant regulation of CRTC1 is also observed in oncogenesis; oncogenic fusion proteins such as CRTC1–MAML2, which merge the CREB coactivator domain of CRTC1 with Notch pathway regulators, drive constitutive CREB transcriptional activity in mucoepidermoid carcinomas."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings underscore CRTC1’s multifaceted roles in coupling extracellular signals to transcriptional outcomes that govern neuronal plasticity, energy balance, circadian regulation, and, when dysregulated, contribute to disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Toh Hean Ch'ng, Besim Uzgil, Peter Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2012.05.027"}], "href": "https://doi.org/10.1016/j.cell.2012.05.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22770221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22770221"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Aarti Jagannath, Rachel Butler, Sofia I H Godinho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CRTC1-SIK1 pathway regulates entrainment of the circadian clock."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2013.08.004"}], "href": "https://doi.org/10.1016/j.cell.2013.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23993098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23993098"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hyunkyung Jeong, Dena E Cohen, Libin Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2559"}], "href": "https://doi.org/10.1038/nm.2559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22179316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22179316"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Judith Y Altarejos, Naomi Goebel, Michael D Conkright, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Creb1 coactivator Crtc1 is required for energy balance and fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.1866"}], "href": "https://doi.org/10.1038/nm.1866"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18758446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18758446"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jessica E Rexach, Peter M Clark, Daniel E Mason, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nchembio.770"}], "href": "https://doi.org/10.1038/nchembio.770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22267118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22267118"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Céline E Riera, Mark O Huising, Patricia Follett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.03.051"}], "href": "https://doi.org/10.1016/j.cell.2014.03.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24855942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24855942"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Judit España, Jorge Valero, Alfredo J Miñano-Molina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "beta-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2154-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.2154-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20631169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20631169"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Marta Winnes, Lena Mölne, Mart Suurküla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20440"}], "href": "https://doi.org/10.1002/gcc.20440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17334997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17334997"}]}]}]}
Synonyms	TORC-1, MAML2, MECT1, TORC1, WAMTP1
Proteins	CRTC1_HUMAN
NCBI Gene ID	23373
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CRTC1 has 6,541 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for CRTC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CRTC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CRTC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CRTC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CRTC1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CRTC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CRTC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CRTC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CRTC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CRTC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CRTC1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CRTC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CRTC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with CRTC1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CRTC1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CRTC1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CRTC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CRTC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CRTC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CRTC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CRTC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CRTC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CRTC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CRTC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CRTC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CRTC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CRTC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CRTC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CRTC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CRTC1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CRTC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CRTC1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CRTC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CRTC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CRTC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CRTC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CRTC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CRTC1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CRTC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CRTC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CRTC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CRTC1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.