| Name | CSAG family, member 2 |
| Description | Predicted to be involved in response to xenobiotic stimulus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA survey of the provided abstracts reveals that none specifically address the function of CSAG2. Instead, the studies focus on mechanisms of nuclear transport mediated by various importin proteins. For instance, one study demonstrated that in intestinal epithelial cells, prohibitin (PHB) regulates the nuclear translocation of NF‑κB by modulating the levels of importin‑α3, thereby protecting cells against tumor necrosis factor‑α–induced barrier dysfunction and inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports emphasize the critical roles of importin family members in tumor biology and differentiation. In glioblastoma multiforme, for example, the miR‑181 family—especially miR‑181b—suppresses epithelial‑mesenchymal transition and tumor progression by targeting KPNA4, an importin‑α isoform, while studies in murine embryonic stem cells and testicular germ cells highlight distinct functions for importins in maintaining pluripotency versus commitment to differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional work has explored the roles of importin‑α isoforms in controlling the nuclear import of transcription factors in the nervous system and kidney. For example, importin‑α4 modulates c‑Fos nuclear entry in peripheral sensory neurons to influence pain responsiveness, and importin‑α–mediated nuclear translocation of dendrin plays a key role in podocyte injury, suggesting that regulation of nuclear import is vital for cellular stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile these findings collectively underscore the importance of regulated nuclear import in controlling diverse cellular functions—from inflammatory signaling and differentiation to oncogenic and stress‐related pathways—the function of CSAG2 is not addressed in these abstracts. If CSAG2 plays a role in similar transport or regulatory pathways, its activity remains to be elucidated in the literature.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cathryn A Hogarth, David A Jans, Kate L Loveland "}, {"type": "b", "children": [{"type": "t", "text": "Subcellular distribution of importins correlates with germ cell maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.21238"}], "href": "https://doi.org/10.1002/dvdy.21238"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17654710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17654710"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Arianne L Theiss, Aaron K Jenkins, Ngozi I Okoro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-05-0361"}], "href": "https://doi.org/10.1091/mbc.e09-05-0361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19710421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19710421"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Julia C Young, Andrew T Major, Yoichi Miyamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.10-176941"}], "href": "https://doi.org/10.1096/fj.10-176941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21840941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21840941"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Julia C Young, Jennifer D Ly-Huynh, Helen Lescesen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The nuclear import factor importin α4 can protect against oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2013.06.007"}], "href": "https://doi.org/10.1016/j.bbamcr.2013.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23773962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23773962"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hongjun Wang, Tao Tao, Wei Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep13072"}], "href": "https://doi.org/10.1038/srep13072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26283154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26283154"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Letizia Marvaldi, Nicolas Panayotis, Stefanie Alber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Importin α3 regulates chronic pain pathways in peripheral sensory neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aaz5875"}], "href": "https://doi.org/10.1126/science.aaz5875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32792398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32792398"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Maulana A Empitu, Mitsuhiro Kikyo, Naritoshi Shirata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of Importin- α -Mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.0000000000000150"}], "href": "https://doi.org/10.1681/ASN.0000000000000150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37134307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37134307"}]}]}]}
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| Synonyms | CSAG3B, TRAG3, CSAG3, TRAG-3 |
| Proteins | CSAG2_HUMAN |
| NCBI Gene ID | 102723547 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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CSAG2 has 1,205 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 42 datasets.
Click the + buttons to view associations for CSAG2 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CSAG2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of CSAG2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CSAG2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of CSAG2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of CSAG2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of CSAG2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with CSAG2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of CSAG2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with CSAG2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CSAG2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with CSAG2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CSAG2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of CSAG2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing CSAG2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of CSAG2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with CSAG2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing CSAG2 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of CSAG2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of CSAG2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of CSAG2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of CSAG2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of CSAG2 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of CSAG2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of CSAG2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of CSAG2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of CSAG2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of CSAG2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of CSAG2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain CSAG2 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of CSAG2 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of CSAG2 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| NURSA Protein Complexes | protein complexs containing CSAG2 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving CSAG2 protein from the Wikipathways PFOCR 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of CSAG2 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CSAG2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CSAG2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of CSAG2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of CSAG2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of CSAG2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of CSAG2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with CSAG2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with CSAG2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
