CSDE1 Gene

Name	cold shock domain containing E1, RNA-binding
Description	Enables RISC complex binding activity; RNA stem-loop binding activity; and lncRNA binding activity. Involved in IRES-dependent viral translational initiation; regulation of gene expression; and stress granule assembly. Located in Golgi apparatus; cytosol; and plasma membrane. Part of CRD-mediated mRNA stability complex and mCRD-mediated mRNA stability complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CSDE1 (cold shock domain‐containing E1), also known as UNR, is a multifunctional RNA‐binding protein that plays a pivotal role in post‐transcriptional gene regulation by modulating mRNA stability and translation in a context‐dependent manner. In cancer, elevated CSDE1 levels have been linked to enhanced invasion, metastasis, and malignant progression through its control of translation elongation and termination of key pro‐oncogenic transcripts (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In parallel, CSDE1 can also exert tumor‐suppressive effects; for instance, in oncogene‐induced senescence its activity promotes the stability of senescence‐associated secretory phenotype (SASP) mRNAs and represses translation of oncogenic regulators like YBX1, thereby enforcing a stable growth arrest (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " During development, CSDE1 is crucial for maintaining the undifferentiated state of human embryonic stem cells and for preventing premature neurogenesis by post‐transcriptionally modulating factors such as FABP7 and vimentin (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Its importance extends to the nervous system where it ensures proper radial and tangential migration of precerebellar neurons, a function essential for correct brain development (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, CSDE1 is implicated in hematopoietic differentiation processes such as erythropoiesis, where its fine-tuning of mRNA translation likely contributes to the maintenance of protein homeostasis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Recent integrative analyses highlight the dualistic nature of CSDE1 in translational reprogramming, demonstrating that it can act as both an activator and a repressor, depending on its interacting protein partners and the specific mRNA targets involved (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Additionally, its expression and function can be modulated by upstream noncoding RNAs, as observed in lung cancer where factors like LINC00205 recruit associated proteins to stabilize CSDE1 mRNA, thereby promoting malignant phenotypes (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies establish CSDE1 as a critical mediator of translational reprogramming with broad implications in development, cellular homeostasis, and cancer progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Laurence Wurth, Panagiotis Papasaikas, David Olmeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.10.004"}], "href": "https://doi.org/10.1016/j.ccell.2016.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27908735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27908735"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pavan Kumar Kakumani, Tanit Guitart, Francois Houle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01767-9"}], "href": "https://doi.org/10.1038/s41388-021-01767-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33833398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33833398"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rosario Avolio, Marta Inglés-Ferrándiz, Annagiulia Ciocia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2021.110211"}], "href": "https://doi.org/10.1016/j.celrep.2021.110211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35021076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35021076"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hyun Ju Lee, Deniz Bartsch, Cally Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-01744-5"}], "href": "https://doi.org/10.1038/s41467-017-01744-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29129916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29129916"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "H Kobayashi, D Kawauchi, Y Hashimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The control of precerebellar neuron migration by RNA-binding protein Csde1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2013.08.055"}], "href": "https://doi.org/10.1016/j.neuroscience.2013.08.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24012837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24012837"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kat S Moore, Nurcan Yagci, Floris van Alphen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-20518-7"}], "href": "https://doi.org/10.1038/s41598-018-20518-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29422612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29422612"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ao-Xiang Guo, Jia-Jia Cui, Lei-Yun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of CSDE1 in translational reprogramming and human diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-019-0496-2"}], "href": "https://doi.org/10.1186/s12964-019-0496-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31987048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31987048"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Peng Xie, Yesong Guo "}, {"type": "b", "children": [{"type": "t", "text": "LINC00205 promotes malignancy in lung cancer by recruiting FUS and stabilizing CSDE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20190701"}], "href": "https://doi.org/10.1042/BSR20190701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32808651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32808651"}]}]}]}
Synonyms	D1S155E
Proteins	CSDE1_HUMAN
NCBI Gene ID	7812
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CSDE1 has 9,939 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 112 datasets.

Click the + buttons to view associations for CSDE1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CSDE1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CSDE1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CSDE1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CSDE1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CSDE1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CSDE1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CSDE1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CSDE1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CSDE1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CSDE1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CSDE1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CSDE1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CSDE1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CSDE1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CSDE1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CSDE1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CSDE1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CSDE1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing CSDE1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing CSDE1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CSDE1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CSDE1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CSDE1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CSDE1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CSDE1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CSDE1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CSDE1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CSDE1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CSDE1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CSDE1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CSDE1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CSDE1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CSDE1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CSDE1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CSDE1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CSDE1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CSDE1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CSDE1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CSDE1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CSDE1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CSDE1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.