CSF2RB Gene

HGNC Family	Fibronectin type III domain containing, CD molecules (CD)
Name	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Description	The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCSF2RB encodes the common β chain shared by the receptors for interleukin‑3 (IL‑3), granulocyte–macrophage colony‑stimulating factor (GM‑CSF), and IL‑5. As such, it is essential for converting ligand binding at receptor‐specific α subunits into intracellular signals that control hematopoietic cell proliferation, differentiation, and survival. Structural and biochemical studies have revealed that CSF2RB assembles with its partner α subunits to form high‑affinity receptor complexes that trigger downstream signaling cascades—including those mediated by Janus kinases (JAKs) and the PI3K/mTOR pathway—once engaged by cytokines."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDetailed structural analyses have mapped key regions within CSF2RB that are critical for its function. X‑ray crystallography and mutagenesis studies demonstrate that residues in the extracellular domains—especially in domains 1 and 4—help stabilize the receptor complex and facilitate cytokine binding. Kinetic experiments further indicate that CSF2RB contributes to a slow dissociation of the ligand–receptor complex, thus sustaining the signal, while modifications such as N‑glycosylation, although not absolutely required, may fine‑tune receptor activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic and functional studies have also implicated CSF2RB in disease. Variants in CSF2RB and related elements of the IL‑3 pathway have been associated with neuropsychiatric conditions such as schizophrenia, suggesting that altered cytokine signaling may contribute to disease susceptibility. In malignancies, aberrant CSF2RB activation—through mechanisms like FLT3‑ITD‑dependent phosphorylation or somatic mutations (for example, the oncogenic S230I mutation)—has been shown to drive oncogenic signaling in acute myeloid leukemia and breast cancer by hyperactivating pathways such as JAK/STAT and PI3K/mTOR."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}, {"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Barbara J McClure, Timothy R Hercus, Bronwyn A Cambareri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-06-1903"}], "href": "https://doi.org/10.1182/blood-2002-06-1903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393492"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Timothy J Blake, Brendan J Jenkins, Richard J D'Andrea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional cross-talk between cytokine receptors revealed by activating mutations in the extracellular domain of the beta-subunit of the GM-CSF receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12488507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12488507"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "James M Murphy, Sally C Ford, Jane E Olsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402705200"}], "href": "https://doi.org/10.1074/jbc.M402705200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15060062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15060062"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "P D Carr, F Conlan, S Ford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Crystallogr Sect F Struct Biol Cryst Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/S1744309106016812"}], "href": "https://doi.org/10.1107/S1744309106016812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16754968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16754968"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Q Chen, X Wang, F A O'Neill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study of CSF2RB with schizophrenia in Irish family and case - control samples."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.mp.4002051"}], "href": "https://doi.org/10.1038/sj.mp.4002051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17667962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17667962"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Peng Chen, Ke Huang, Guoquan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common SNPs in CSF2RB are associated with major depression and schizophrenia in the Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Biol Psychiatry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/15622975.2010.544328"}], "href": "https://doi.org/10.3109/15622975.2010.544328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21247258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21247258"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tetsuya Ishino, Adrian E Harrington, Meirav Zaks-Zilberman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Slow-dissociation effect of common signaling subunit beta c on IL5 and GM-CSF receptor assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cyto.2007.12.010"}], "href": "https://doi.org/10.1016/j.cyto.2007.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18294864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18294864"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "James M Murphy, Tatiana A Soboleva, Shamaruh Mirza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clarification of the role of N-glycans on the common beta-subunit of the human IL-3, IL-5 and GM-CSF receptors and the murine IL-3 beta-receptor in ligand-binding and receptor activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cyto.2008.02.010"}], "href": "https://doi.org/10.1016/j.cyto.2008.02.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18374598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18374598"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shilong Sun, Fan Wang, Jun Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2008.05.029"}], "href": "https://doi.org/10.1016/j.neulet.2008.05.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18547720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18547720"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "V Moskvina, N Craddock, P Holmans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2008.133"}], "href": "https://doi.org/10.1038/mp.2008.133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19065143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19065143"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mamoon Rashid, Rizwan Ali, Bader Almuzzaini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.4106"}], "href": "https://doi.org/10.1002/cam4.4106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34729943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34729943"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Anne Charlet, Max Kappenstein, Philip Keye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-021-01462-4"}], "href": "https://doi.org/10.1038/s41375-021-01462-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34750506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34750506"}]}]}]}
Synonyms	SMDP5, betaGMR, CDW131, IL3RB, IL5RB, CD131
Proteins	IL3RB_HUMAN
NCBI Gene ID	1439
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CSF2RB has 6,192 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for CSF2RB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CSF2RB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CSF2RB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CSF2RB gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CSF2RB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CSF2RB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CSF2RB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving CSF2RB protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CSF2RB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CSF2RB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CSF2RB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of CSF2RB gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CSF2RB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CSF2RB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CSF2RB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CSF2RB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CSF2RB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CSF2RB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with CSF2RB gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CSF2RB gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CSF2RB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CSF2RB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CSF2RB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CSF2RB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CSF2RB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing CSF2RB protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CSF2RB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CSF2RB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CSF2RB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CSF2RB gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CSF2RB gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CSF2RB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CSF2RB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CSF2RB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CSF2RB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CSF2RB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CSF2RB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CSF2RB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for CSF2RB protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CSF2RB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CSF2RB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CSF2RB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.