{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cancer/testis antigen family 45 member A10 (CT45A10) is emerging as a multifunctional protein with promising applications in cancer therapeutics. In high‐grade serous ovarian cancer, CT45A10 has been shown to directly interact with the PP4 phosphatase complex, thereby regulating its activity. This regulation appears to promote the accumulation of DNA damage, which in turn enhances the sensitivity of tumor cells to platinum-based chemotherapy. Moreover, immunopeptidomics studies have revealed that peptides derived from CT45A10, when presented on HLA class I molecules, are capable of activating patient-derived cytotoxic T cells, suggesting that CT45A10 not only influences DNA damage response but also contributes to antitumor immune recognition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, proteomic strategies employing multiprotease digestion in human testis tissues have successfully validated CT45A10 as an exemplary missing protein. This identification supports its restricted expression profile—typical of cancer/testis antigens—and reinforces its potential as both a prognostic biomarker and a target for immunotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fabian Coscia, Ernst Lengyel, Jaikumar Duraiswamy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2018.08.065"}], "href": "https://doi.org/10.1016/j.cell.2018.08.065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30241606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30241606"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yihao Wang, Yang Chen, Yao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multi-Protease Strategy Identifies Three PE2 Missing Proteins in Human Testis Tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.7b00340"}], "href": "https://doi.org/10.1021/acs.jproteome.7b00340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28959888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28959888"}]}]}]}