{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the cancer/testis antigen CT83 as a tumor‐specific biomarker with oncogenic potential in several malignancies, most notably in triple‐negative breast cancer, lung adenocarcinoma, and gastric cancer. Under normal conditions, CT83 expression is restricted to testicular tissue; however, its aberrant activation in tumors occurs via epigenetic dysregulation—such as hypomethylation at its X‐chromosome locus—which may trigger cell cycle signaling and promote oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In triple‐negative breast cancer, CT83 has been identified as the most specific gene, with its abnormal activation correlating with poor overall survival. The rarity of copy number variations and mutations in CT83 further underscores its potential as a selective target for immunotherapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similarly, in lung adenocarcinoma, CT83 expression is significantly associated with patient prognosis. Prognostic models that incorporate CT83-related differentially expressed genes have demonstrated its utility in predicting overall survival, suggesting that CT83 may play a role in modulating tumor cell behavior independent of overt immune infiltration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In gastric cancer, CT83 is included in multi‐gene prognostic signatures and its expression has been linked to tumor progression and clinical outcome. In these models, CT83 status contributes to risk stratification and may serve as a useful biomarker for early diagnosis and prognostication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, comprehensive analyses in triple‐negative breast cancer have demonstrated that, when combined with other markers such as FABP7, CT83 expression is significantly correlated with overall survival, supporting its role as an independent prognostic factor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the significance of CT83 as both an oncogenic driver and a prognostic biomarker across multiple cancer types, warranting further investigation into CT83-targeted approaches for cancer immunotherapy.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chen Chen, Dan Gao, Jinlong Huo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-91290-4"}], "href": "https://doi.org/10.1038/s41598-021-91290-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34108519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34108519"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yongmei Wang, Guimin Zhang, Ruixian Wang "}, {"type": "b", "children": [{"type": "t", "text": "Six CT83-related Genes-based Prognostic Signature for Lung Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1871520621666210713112630"}], "href": "https://doi.org/10.2174/1871520621666210713112630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34259140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34259140"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kojun Tsuji, Takanori Tsujimura, Shogo Sakai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00233.2020"}], "href": "https://doi.org/10.1152/ajpgi.00233.2020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32878469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32878469"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Siwei Pan, Qi Gao, Qingchuan Chen, et al. 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