CXCL16 Gene

HGNC Family	Endogenous ligands, Chemokine ligands (CCL)
Name	chemokine (C-X-C motif) ligand 16
Description	Enables chemokine activity. Involved in several processes, including positive regulation of cell growth; response to tumor necrosis factor; and response to type II interferon. Located in extracellular space. Biomarker of COVID-19 and systemic scleroderma. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CXCL16 is a unique chemokine that functions in a dual capacity: as a transmembrane molecule serving as an adhesion and scavenger receptor and as a soluble chemoattractant for activated T cells and natural killer T cells. In its membrane‐bound form, CXCL16 mediates cell–cell adhesion and facilitates uptake of oxidized lipoproteins and bacteria, thereby contributing to pathogen clearance and foam cell formation in atherosclerotic lesions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Proteolytic cleavage—primarily mediated by ADAM10—releases the soluble form of CXCL16, which acts as a potent chemoattractant by engaging its receptor CXCR6 on various immune cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": " This regulated conversion is essential not only for proper immune cell recruitment during infections and tissue injury but also for maintaining vascular homeostasis. Inflammatory cytokines, such as interferon‐γ and tumor necrosis factor‐α, are strong inducers of CXCL16 expression, linking its upregulation to chronic inflammatory conditions including atherosclerosis and rheumatoid arthritis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In vascular smooth muscle cells, CXCL16 contributes to foam cell formation via enhanced uptake of oxidized low‐density lipoprotein"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while in the liver, its expression by cholangiocytes and endothelial cells supports the adhesion and retention of lymphocytes, thereby orchestrating local immune surveillance and inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In the context of tumor biology, CXCL16 displays divergent roles: it can promote tumor cell migration and invasion in aggressive cancers such as prostate carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", whereas in renal cell carcinoma, higher CXCL16 expression is associated with reduced cell migration and improved patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Moreover, in glioma and the glioma microenvironment, CXCL16 not only is expressed and shed by tumor cells but also modulates microglial polarization toward phenotypes that can influence tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Additionally, CXCL16 has been implicated in platelet activation and adhesion, reflecting its broader role in linking vascular inflammation with thrombotic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Collectively, these findings underscore the pivotal role of CXCL16 as an integrator of immune, metabolic, and vascular signals in both homeostatic and disease settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Soeren Abel, Christian Hundhausen, Rolf Mentlein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.10.6362"}], "href": "https://doi.org/10.4049/jimmunol.172.10.6362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15128827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15128827"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peter J Gough, Kyle J Garton, Paul T Wille, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.6.3678"}], "href": "https://doi.org/10.4049/jimmunol.172.6.3678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15004171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15004171"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takeshi Shimaoka, Takashi Nakayama, Noriaki Kume, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: SR-PSOX/CXC chemokine ligand 16 mediates bacterial phagocytosis by APCs through its chemokine domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.171.4.1647"}], "href": "https://doi.org/10.4049/jimmunol.171.4.1647"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12902461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12902461"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Frederic Geissmann, Thomas O Cameron, Stephane Sidobre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.0030113"}], "href": "https://doi.org/10.1371/journal.pbio.0030113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15799695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15799695"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Takeshi Shimaoka, Takashi Nakayama, Noriko Fukumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.1003465"}], "href": "https://doi.org/10.1189/jlb.1003465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14634054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14634054"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mathis Heydtmann, Patricia F Lalor, J Albertus Eksteen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.174.2.1055"}], "href": "https://doi.org/10.4049/jimmunol.174.2.1055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15634930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15634930"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Huang, Xiao-Yong Zhu, Mei-Rong Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human trophoblasts recruited T lymphocytes and monocytes into decidua by secretion of chemokine CXCL16 and interaction with CXCR6 in the first-trimester pregnancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.4.2367"}], "href": "https://doi.org/10.4049/jimmunol.180.4.2367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18250446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18250446"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dirk M Wuttge, Xinghua Zhou, Yuri Sheikine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.ATV.0000124102.11472.36"}], "href": "https://doi.org/10.1161/01.ATV.0000124102.11472.36"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14988089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14988089"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Paul Gutwein, Mohamed Sadek Abdel-Bakky, Anja Schramme, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.080960"}], "href": "https://doi.org/10.2353/ajpath.2009.080960"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19435795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19435795"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bysani Chandrasekar, Sailaja Bysani, Srinivas Mummidi "}, {"type": "b", "children": [{"type": "t", "text": "CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311660200"}], "href": "https://doi.org/10.1074/jbc.M311660200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14625285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14625285"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dick Wågsäter, Peder S Olofsson, Lars Norgren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chemokine and scavenger receptor CXCL16/SR-PSOX is expressed in human vascular smooth muscle cells and is induced by interferon gamma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.10.160"}], "href": "https://doi.org/10.1016/j.bbrc.2004.10.160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15555552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15555552"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alessia Omenetti, Wing-Kin Syn, Youngmi Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.23019"}], "href": "https://doi.org/10.1002/hep.23019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19575365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19575365"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yi Lu, Jianhua Wang, Yang Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-07-0277"}], "href": "https://doi.org/10.1158/1541-7786.MCR-07-0277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18344492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18344492"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Achinto Saha, Songyeon Ahn, Jorge Blando, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proinflammatory CXCL12-CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-0284"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-0284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28687617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28687617"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Paul Gutwein, Anja Schramme, Nina Sinke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2008.10.023"}], "href": "https://doi.org/10.1016/j.ejca.2008.10.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19070478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19070478"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Andreas Ludwig, Alexander Schulte, Cathrin Schnack, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2005.03123.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2005.03123.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15934948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15934948"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Francesca Lepore, Giuseppina D'Alessandro, Fabrizio Antonangeli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCL16/CXCR6 Axis Drives Microglia/Macrophages Phenotype in Physiological Conditions and Plays a Crucial Role in Glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2018.02750"}], "href": "https://doi.org/10.3389/fimmu.2018.02750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30542347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30542347"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Oliver Borst, Patrick Münzer, Sergios Gatidis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/Akt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.112.276444"}], "href": "https://doi.org/10.1161/CIRCRESAHA.112.276444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22927331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22927331"}]}]}]}
Synonyms	SRPSOX, SR-PSOX, CXCLG16
Proteins	CXL16_HUMAN
NCBI Gene ID	58191
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CXCL16 has 7,014 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for CXCL16 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CXCL16 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by CXCL16 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CXCL16 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CXCL16 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CXCL16 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CXCL16 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CXCL16 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CXCL16 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CXCL16 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CXCL16 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CXCL16 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CXCL16 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CXCL16 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CXCL16 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CXCL16 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CXCL16 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CXCL16 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CXCL16 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CXCL16 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CXCL16 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CXCL16 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CXCL16 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CXCL16 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with CXCL16 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of CXCL16 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CXCL16 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CXCL16 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CXCL16 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CXCL16 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CXCL16 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CXCL16 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CXCL16 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CXCL16 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of CXCL16 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CXCL16 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with CXCL16 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with CXCL16 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with CXCL16 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CXCL16 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CXCL16 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of CXCL16 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.