CXCR4 Gene

HGNC Family	CD molecules (CD), G protein-coupled receptors
Name	chemokine (C-X-C motif) receptor 4
Description	This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CXCR4 is a G protein–coupled receptor for stromal cell–derived factor–1 (SDF‐1, also known as CXCL12) that orchestrates multiple cellular processes by regulating directed migration, homing, survival, and adhesion. In the tumor microenvironment, for example, carcinoma‐associated fibroblasts secrete SDF‐1 to stimulate CXCR4 on malignant cells, thereby enhancing tumor growth, angiogenesis, and organ‐specific metastasis in breast and prostate cancers"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In pancreatic ductal adenocarcinoma, targeting CXCR4 with inhibitors such as AMD3100 disrupts SDF‐1–mediated immune exclusion of T cells and, when combined with checkpoint blockade, restores antitumor immunity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Structural studies have revealed unique features of CXCR4—including its ligand‐binding pocket and dimerization interface—that are critical for its interaction with natural ligands as well as with the HIV‐1 glycoprotein gp120"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and for its signaling activity in different pathological settings. Moreover, CXCR4 plays an important role in mediating inflammatory cell recruitment. Activation of CXCR4 by factors such as macrophage migration inhibitory factor drives integrin‐dependent leukocyte arrest and chemotaxis, processes that contribute to the development of atherosclerosis and other inflammatory diseases"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while its expression on circulating fibrocytes and monocytes facilitates their migration to sites of tissue injury or fibrosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its roles in cancer and inflammation, CXCR4 is key to normal regenerative processes; for instance, it mediates the recruitment of bone marrow–derived cells and mesenchymal stem cells that contribute to neovascularization after myocardial infarction and to endochondral bone repair following injury"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Furthermore, its function in stem cell trafficking is underscored by reviews linking the SDF‐1–CXCR4 axis to mobilization and homing of normal and cancer stem cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "and by the ability of hematopoietic as well as nonhematopoietic cells to respond to SDF‐1 gradients.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Dysregulation of CXCR4 signaling is also implicated in immunodeficiency, as exemplified by WHIM syndrome, where truncating mutations in the cytoplasmic tail of CXCR4 lead to aberrant signal transduction and impaired leukocyte trafficking."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In addition, oncogenic pathways—such as NF-κB and HER2 signaling—can upregulate CXCR4 expression, thereby promoting cancer cell motility and metastasis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, cytokine stimulation and antimicrobial peptides (for example, LL-37) can enhance CXCR4 expression on immune cells, further influencing their trafficking dynamics in inflammatory contexts"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Together with therapeutic strategies aimed at disrupting SDF‐1–CXCR4 interactions in the tumor microenvironment"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", these findings highlight the pivotal role of CXCR4 in regulating cell migration, survival, and tissue organization in both normal physiology and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Akira Orimo, Piyush B Gupta, Dennis C Sgroi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2005.02.034"}], "href": "https://doi.org/10.1016/j.cell.2005.02.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15882617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15882617"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Russell S Taichman, Carlton Cooper, Evan T Keller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11912162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11912162"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gregory Helbig, Kent W Christopherson, Poornima Bhat-Nakshatri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M300609200"}], "href": "https://doi.org/10.1074/jbc.M300609200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12690099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12690099"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan M Li, Yong Pan, Yongkun Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2004.09.027"}], "href": "https://doi.org/10.1016/j.ccr.2004.09.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15542430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15542430"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christine Feig, James O Jones, Matthew Kraman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1320318110"}], "href": "https://doi.org/10.1073/pnas.1320318110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24277834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24277834"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Beili Wu, Ellen Y T Chien, Clifford D Mol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1194396"}], "href": "https://doi.org/10.1126/science.1194396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20929726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20929726"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jürgen Bernhagen, Regina Krohn, Hongqi Lue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1567"}], "href": "https://doi.org/10.1038/nm1567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17435771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17435771"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Roderick J Phillips, Marie D Burdick, Kurt Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI20997"}], "href": "https://doi.org/10.1172/JCI20997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15286810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15286810"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Petronela Ancuta, Ravi Rao, Ashlee Moses, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fractalkine preferentially mediates arrest and migration of CD16+ monocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20022156"}], "href": "https://doi.org/10.1084/jem.20022156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12810688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12810688"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "J Dawn Abbott, Yan Huang, Dingang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000147780.30124.CF"}], "href": "https://doi.org/10.1161/01.CIR.0000147780.30124.CF"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15533866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15533866"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Toshiyuki Kitaori, Hiromu Ito, Edward M Schwarz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.24330"}], "href": "https://doi.org/10.1002/art.24330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19248097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19248097"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Magda Kucia, Ryan Reca, Katarzyna Miekus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1634/stemcells.2004-0342"}], "href": "https://doi.org/10.1634/stemcells.2004-0342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15888687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15888687"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Paolo A Hernandez, Robert J Gorlin, John N Lukens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1149"}], "href": "https://doi.org/10.1038/ng1149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12692554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12692554"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Monisha G Scott, Donald J Davidson, Michael R Gold, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.7.3883"}], "href": "https://doi.org/10.4049/jimmunol.169.7.3883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12244186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12244186"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "David K Jin, Koji Shido, Hans-Georg Kopp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1400"}], "href": "https://doi.org/10.1038/nm1400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16648859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16648859"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Urszula M Domanska, Roeliene C Kruizinga, Wouter B Nagengast, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A review on CXCR4/CXCL12 axis in oncology: no place to hide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2012.05.005"}], "href": "https://doi.org/10.1016/j.ejca.2012.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22683307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22683307"}]}]}]}
Synonyms	D2S201E, NPYY3R, NPYRL, CD184, WHIMS, HSY3RR, NPY3R, LAP3, LCR1, LESTR, FB22, LAP-3, WHIM, HM89
Proteins	CXCR4_HUMAN
NCBI Gene ID	7852
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CXCR4 has 19,515 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 132 datasets.

Click the + buttons to view associations for CXCR4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

CXCR4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CXCR4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of CXCR4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CXCR4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CXCR4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of CXCR4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CXCR4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving CXCR4 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CXCR4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CXCR4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CXCR4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CXCR4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CXCR4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with CXCR4 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with CXCR4 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with CXCR4 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CXCR4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of CXCR4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CXCR4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with CXCR4 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with CXCR4 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CXCR4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CXCR4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CXCR4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CXCR4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CXCR4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CXCR4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with CXCR4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with CXCR4 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with CXCR4 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by CXCR4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving CXCR4 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CXCR4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CXCR4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CXCR4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CXCR4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with CXCR4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with CXCR4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for CXCR4 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CXCR4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CXCR4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.