| Name | chromosome X open reading frame 49B |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CXorf49B is encoded by an open reading frame initially identified in multiple cell and tissue proteomes and, although its function remains largely uncharacterized, recent studies suggest that it may be involved in processes related to oxidative stress and cellular proliferation. In one study, treatment of cells with the lipid peroxidation product 4‐hydroxy‐2‐nonenal (HNE) led to the formation of HNE adducts on a protein designated as CXorf49, implying that oxidative modifications may alter its function and potentially contribute to stress‐induced cellular damage and immune activation, processes that are relevant to endothelial dysfunction and atherosclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another study focused on breast cancer morphology, CXorf49B was identified as one of eight differentially expressed genes associated with overall tumour grade and its pathological components; these genes are linked to cellular proliferation, differentiation, and metabolic processes, suggesting that CXorf49B may also have a role in driving tumour phenotype and behaviour."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alessia Arcaro, Martina Daga, Giovanni Paolo Cetrangolo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Generation of Adducts of 4-Hydroxy-2-nonenal with Heat Shock 60 kDa Protein 1 in Human Promyelocytic HL-60 and Monocytic THP-1 Cell Lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/296146"}], "href": "https://doi.org/10.1155/2015/296146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26078803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26078803"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Emad A Rakha, Mansour Alsaleem, Khloud A ElSharawy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Visual histological assessment of morphological features reflects the underlying molecular profile in invasive breast cancer: a morphomolecular study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/his.14199"}], "href": "https://doi.org/10.1111/his.14199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32618014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32618014"}]}]}]}
|
| Synonyms | CXorf49 |
| NCBI Gene ID | 100132994 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
CXORF49B has 431 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 20 datasets.
Click the + buttons to view associations for CXORF49B from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of CXORF49B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of CXORF49B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of CXORF49B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with CXORF49B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of CXORF49B gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of CXORF49B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of CXORF49B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of CXORF49B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of CXORF49B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate CXORF49B protein from the Kinase Library Serine Threonine Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of CXORF49B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of CXORF49B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of CXORF49B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of CXORF49B gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of CXORF49B gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of CXORF49B gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of CXORF49B gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of CXORF49B gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of CXORF49B gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of CXORF49B gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
