{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n CXorf51B, a gene located on the X chromosome, has emerged as a candidate factor in the host response to infection by Mycobacterium tuberculosis, the causative agent of tuberculosis (TB)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Evidence from transcriptomic analyses in TB patient samples indicates that CXorf51B expression is altered during infection. This differential regulation suggests that the protein encoded by CXorf51B may be involved in modulating inflammatory signaling and cell survival pathways, providing a potential mechanism by which the host attempts to balance pathogen clearance with the prevention of excessive tissue damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Such findings imply that CXorf51B could serve both as a biomarker for TB pathogenesis and as a potential therapeutic target, warranting further investigation into its role in the immune response and its contribution to disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haiko Schurz, Craig J Kinnear, Chris Gignoux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2018.00678"}], "href": "https://doi.org/10.3389/fgene.2018.00678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30713548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30713548"}]}]}]}