{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe abstract (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "examines a ∼4‐Mb deletion region on human chromosome 15q11–q13, which is implicated in Prader–Willi and Angelman syndromes, and it details a cluster of four nonimprinted genes located between breakpoints BP1 and BP2—namely CYFIP1, GCP5, NIPA1, and NIPA2. These genes, conserved across vertebrate species, are expressed in a wide variety of tissues and display asynchronous replication timing in mouse models, suggesting a potential regulatory function in genomic organization as well as roles in cellular transport (NIPA1 and NIPA2) and other processes.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that while the study provides insights into the functions and evolutionary dynamics of the genes within this critical region, no specific mention or functional characterization of CXXC1P1 is provided in the abstract. As such, its role remains undetermined based on this source alone.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J-H Chai, D P Locke, J M Greally, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/378816"}], "href": "https://doi.org/10.1086/378816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14508708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14508708"}]}]}]}