{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCYFIP2 is a multifunctional protein that plays a central role in the regulation of actin dynamics and synaptic function. As a key component of the WAVE regulatory complex, CYFIP2 interacts with the fragile X mental retardation protein (FMRP) to modulate posttranscriptional gene expression and cytoskeletal remodeling. Its involvement in coordinating actin polymerization is critical for neurite outgrowth, dendritic spine morphology, and the transport of vesicular carriers from the trans‐Golgi network. In neurodevelopment, de novo CYFIP2 variants – including hotspot mutations such as the R87C change that disrupts its interface with other WRC components – have been linked to a spectrum of disorders, ranging from Fragile X syndrome and autism spectrum disorders to intellectual disability, seizures, and neurodegeneration (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its neural functions, CYFIP2 serves as a p53‐inducible proapoptotic factor that contributes to cell death through caspase activation. In colorectal cancer models, for example, CYFIP2 upregulation following IMP-1 knockdown promotes apoptosis—a response that can be mitigated by CYFIP2 suppression. The identification of recurrent, protein‐damaging hotspot mutations in pancreatic neuroendocrine neoplasms and interactions with kinases such as NUAK2 in cervical cancer further implicate CYFIP2 in tumor progression, epithelial-to-mesenchymal transition, and possibly immune infiltration. Candidate gene studies have even extended its potential involvement to disorders like asthma, underscoring the diverse biological and clinical implications of CYFIP2 dysregulation (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mihaela Anitei, Christoph Stange, Irina Parshina, et al. 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