DAAM1 Gene

Name	dishevelled associated activator of morphogenesis 1
Description	Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Dishevelled‐associated activator of morphogenesis 1 (DAAM1) is a diaphanous‐related formin that functions as a critical mediator linking noncanonical Wnt/planar cell polarity (PCP) signals to downstream actin cytoskeletal remodeling. In response to Wnt ligands, DAAM1 interacts with Dishevelled to activate RhoA signaling cascades, thereby coupling extracellular cues to intracellular actin nucleation, elongation, and bundling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " \n These events underlie the formation of contractile stress fibers and filopodial protrusions, in part through interactions with other actin regulators such as Profilin, fascin, and components of the actomyosin network.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In developmental systems, DAAM1 is essential for proper tissue morphogenesis. It regulates cytoskeletal organization required for cardiac development—where its deficiency leads to severe cardiac defects and noncompaction cardiomyopathy—as well as for the coordinated cell polarity in migrating cells, including centrosome and Golgi reorientation during wound healing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " \n Moreover, its actin‐bundling activity plays a pivotal role in filopodia integrity, supporting proper cell–cell contacts and directional migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cancer contexts, DAAM1 contributes to aggressive cellular behaviors. In ovarian and breast cancers, for example, upregulated DAAM1 is associated with enhanced noncanonical Wnt/PCP signaling, promoting RhoA‐dependent stress fiber formation and increased cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": " \n This evidence underscores DAAM1’s dual role in mediating both normal morphogenetic processes and pathological cell migration.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies demonstrate that DAAM1 serves as an integral link between noncanonical Wnt/PCP signaling and actin dynamics. By orchestrating RhoA activation and modulating actin assembly, DAAM1 coordinates cell polarity, cytoskeletal organization, and migration in diverse settings ranging from embryonic development to cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masaru Katoh "}, {"type": "b", "children": [{"type": "t", "text": "WNT/PCP signaling pathway and human cancer (review)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16273260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16273260"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pontus Aspenström, Ninna Richnau, Ann-Sofi Johansson "}, {"type": "b", "children": [{"type": "t", "text": "The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2006.03.013"}], "href": "https://doi.org/10.1016/j.yexcr.2006.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16630611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16630611"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Akira Sato, Deepak K Khadka, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.02590"}], "href": "https://doi.org/10.1242/dev.02590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17021034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17021034"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Deqiang Li, Mark A Hallett, Wuqiang Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.055566"}], "href": "https://doi.org/10.1242/dev.055566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21177343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21177343"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Su-Fen Ang, Zhuo-shen Zhao, Louis Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DAAM1 is a formin required for centrosome re-orientation during cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0013064"}], "href": "https://doi.org/10.1371/journal.pone.0013064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20927366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20927366"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rieko Ajima, Joseph A Bisson, Jay-Christian Helt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2015.10.003"}], "href": "https://doi.org/10.1016/j.ydbio.2015.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26526197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26526197"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Richa Jaiswal, Dennis Breitsprecher, Agnieszka Collins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The formin Daam1 and fascin directly collaborate to promote filopodia formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2013.06.013"}], "href": "https://doi.org/10.1016/j.cub.2013.06.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23850281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23850281"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "M Asad, M K Wong, T Z Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.302"}], "href": "https://doi.org/10.1038/cddis.2014.302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25032869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25032869"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yichao Zhu, Yinhui Tian, Jun Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0037823"}], "href": "https://doi.org/10.1371/journal.pone.0037823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22655072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22655072"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Irene Rodriguez-Hernandez, Oscar Maiques, Leonie Kohlhammer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-18951-2"}], "href": "https://doi.org/10.1038/s41467-020-18951-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33082334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33082334"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Rong Ju, Pasquale Cirone, Shengda Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1001075107"}], "href": "https://doi.org/10.1073/pnas.1001075107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20351293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20351293"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wei Liu, Akira Sato, Deepak Khadka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of activation of the Formin protein Daam1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0707277105"}], "href": "https://doi.org/10.1073/pnas.0707277105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18162551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18162551"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Michelle Rosado, Cynthia F Barber, Cristina Berciu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical roles for multiple formins during cardiac myofibril development and repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-08-0443"}], "href": "https://doi.org/10.1091/mbc.E13-08-0443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24430873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24430873"}]}]}]}
Proteins	DAAM1_HUMAN
NCBI Gene ID	23002
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DAAM1 has 8,485 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 130 datasets.

Click the + buttons to view associations for DAAM1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DAAM1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DAAM1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DAAM1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DAAM1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DAAM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DAAM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DAAM1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DAAM1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DAAM1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DAAM1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DAAM1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DAAM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DAAM1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DAAM1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DAAM1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DAAM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DAAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DAAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of DAAM1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DAAM1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DAAM1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DAAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DAAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DAAM1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DAAM1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DAAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DAAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DAAM1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DAAM1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with DAAM1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DAAM1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DAAM1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DAAM1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DAAM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DAAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DAAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DAAM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DAAM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DAAM1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DAAM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DAAM1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.