DAB2IP Gene

HGNC Family	C2 domain containing
Name	DAB2 interacting protein
Description	DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DAB2IP, a Ras GTPase‐activating protein, functions as a critical tumor suppressor by acting as a multifunctional scaffold that modulates multiple signal transduction pathways. Its normal expression restrains Ras and PI3K–Akt signaling while promoting pro‐apoptotic ASK1–JNK activity, thereby enforcing cell cycle arrest and apoptosis. Loss or epigenetic silencing of DAB2IP is frequently observed in several cancers—including prostate, breast, lung, and hepatocellular carcinoma—and is associated with an aggressive, metastatic phenotype driven in part by the induction of epithelial‐to‐mesenchymal transition (EMT) and aberrant β‐catenin signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic variants in the DAB2IP gene correlate with an increased risk of aggressive prostate cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while epigenetic mechanisms—including promoter hypermethylation often mediated by oncogenic regulators—contribute to its downregulation in tumors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its intrinsic role in suppressing oncogenic Ras activity, DAB2IP regulates TNF receptor signaling by facilitating the formation of complexes with TRAF2 and ASK1, thereby promoting apoptotic cascades in endothelial and tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, noncoding RNAs contribute to the modulation of DAB2IP expression; for instance, circRNA‐mediated pathways in hepatocellular carcinoma and miR‐26a–dependent regulation in lung cancer highlight the broader impact of DAB2IP on tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies demonstrate that DAB2IP serves as a central node that orchestrates a balance between cell survival and death, and its loss not only unleashes oncogenic Ras signaling but also enables EMT and metastatic dissemination. This multifaceted role underscores the potential of DAB2IP as both a prognostic biomarker and a therapeutic target in diverse cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Furthermore, emerging evidence indicates that DAB2IP can also influence the tumor microenvironment and angiogenesis, further highlighting its broad impact on tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Junxia Min, Alexander Zaslavsky, Giuseppe Fedele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2100"}], "href": "https://doi.org/10.1038/nm.2100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20154697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20154697"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daxing Xie, Crystal Gore, Jun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0908133107"}], "href": "https://doi.org/10.1073/pnas.0908133107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20080667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20080667"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Daxing Xie, Crystal Gore, Jian Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0908458106"}], "href": "https://doi.org/10.1073/pnas.0908458106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19903888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19903888"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "David Duggan, Siqun L Zheng, Michele Knowlton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/djm250"}], "href": "https://doi.org/10.1093/jnci/djm250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18073375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18073375"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hong Chen, Szu-wei Tu, Jer-Tsong Hsieh "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M501379200"}], "href": "https://doi.org/10.1074/jbc.M501379200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15817459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15817459"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hong Chen, Shinichi Toyooka, Adi F Gazdar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208230200"}], "href": "https://doi.org/10.1074/jbc.M208230200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12446720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12446720"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hideaki Dote, Shinichi Toyooka, Kazunori Tsukuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.ccr-03-0236"}], "href": "https://doi.org/10.1158/1078-0432.ccr-03-0236"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15041729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15041729"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Masaaki Yano, Shinichi Toyooka, Kazunori Tsukuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.20531"}], "href": "https://doi.org/10.1002/ijc.20531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15386433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15386433"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Haifeng Zhang, Rong Zhang, Yan Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M407617200"}], "href": "https://doi.org/10.1074/jbc.M407617200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15310755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15310755"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Haifeng Zhang, Haifeng Zhang, Yan Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M701148200"}], "href": "https://doi.org/10.1074/jbc.M701148200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17389591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17389591"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zhenguo Liu, Yaqun Yu, Zebing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2089-9"}], "href": "https://doi.org/10.1038/s41419-019-2089-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31776329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31776329"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiaomin Dang, Aiqun Ma, Lan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergen.2012.01.002"}], "href": "https://doi.org/10.1016/j.cancergen.2012.01.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22469510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22469510"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zhi Wang, Ching-Ping Tseng, Rey-Chen Pong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110568200"}], "href": "https://doi.org/10.1074/jbc.M110568200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11812785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11812785"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Haifeng Zhang, Yun He, Shengchuan Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI36168"}], "href": "https://doi.org/10.1172/JCI36168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19033661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19033661"}]}]}]}
Synonyms	AF9Q34, DIP1/2
Proteins	DAB2P_HUMAN
NCBI Gene ID	153090
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DAB2IP has 5,817 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for DAB2IP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DAB2IP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DAB2IP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DAB2IP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DAB2IP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DAB2IP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DAB2IP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DAB2IP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DAB2IP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DAB2IP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DAB2IP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DAB2IP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DAB2IP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DAB2IP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DAB2IP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DAB2IP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DAB2IP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DAB2IP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DAB2IP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DAB2IP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DAB2IP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DAB2IP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DAB2IP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DAB2IP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DAB2IP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DAB2IP gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DAB2IP gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DAB2IP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DAB2IP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving DAB2IP gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving DAB2IP gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with DAB2IP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DAB2IP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DAB2IP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DAB2IP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DAB2IP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DAB2IP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DAB2IP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DAB2IP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DAB2IP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DAB2IP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with DAB2IP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.