DAZAP1 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	DAZ associated protein 1
Description	In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DAZAP1 is a multifunctional RNA‐binding protein originally identified for its role in spermatogenesis and later found to be expressed widely, where it orchestrates multiple aspects of post‐transcriptional gene regulation. It modulates alternative splicing by binding to specific cis‐elements and interacting with both splicing enhancers and repressors, thereby promoting either exon inclusion or exclusion. This splicing regulatory activity is further fine‐tuned by phosphorylation via the MEK/ERK pathway, which affects its subcellular localization and functional interactions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its splicing function, DAZAP1 acts as an mRNA‐specific translational activator by selectively binding to elements within the 3′ untranslated region of target mRNAs, thereby controlling protein synthesis and influencing cell proliferation. Altered expression levels of DAZAP1 have been implicated in oncogenesis—its dysregulation is observed in cancers such as hepatocellular carcinoma and in fusion events associated with leukemogenesis, which contribute to tumor progression and altered drug sensitivity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, DAZAP1 plays critical roles in germ cell development in both males and females through its interactions with germ cell–specific factors such as DAZL, thereby regulating cell cycle progression, meiosis, and fertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In additional contexts, its association with AU‐rich elements and other RNA‐binding proteins suggests a role in mRNA decay and translational silencing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, DAZAP1 emerges as a central regulator of RNA processing whose coordinated control of splicing and translation is essential for normal cellular function. Its dysregulation can contribute to developmental abnormalities and disease pathogenesis, highlighting its potential as a therapeutic target in conditions where post‐transcriptional gene regulation is impaired.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elisa Goina, Natasa Skoko, Franco Pagani "}, {"type": "b", "children": [{"type": "t", "text": "Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.02253-07"}], "href": "https://doi.org/10.1128/MCB.02253-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18391021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18391021"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rajarshi Choudhury, Sreerupa Ghose Roy, Yihsuan S Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms4078"}], "href": "https://doi.org/10.1038/ncomms4078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24452013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24452013"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hsiang-Ying Chen, Yueh-Hsiang Yu, Pauline H Yen "}, {"type": "b", "children": [{"type": "t", "text": "DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkt746"}], "href": "https://doi.org/10.1093/nar/gkt746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23965306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23965306"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qi Wang, Yaxun Guo, Wentao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.112453"}], "href": "https://doi.org/10.1016/j.yexcr.2020.112453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33358859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33358859"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "V Prima, L Gore, A Caires, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.leu.2403684"}], "href": "https://doi.org/10.1038/sj.leu.2403684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15744350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15744350"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kenta Sasaki, Mana Ono, Kaori Takabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.03.005"}], "href": "https://doi.org/10.1016/j.gene.2018.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29505834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29505834"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chi-Kai Yang, Pauline Yen "}, {"type": "b", "children": [{"type": "t", "text": "Differential translation of Dazap1 transcripts during spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0060873"}], "href": "https://doi.org/10.1371/journal.pone.0060873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23658607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23658607"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hsien-An Pan, Yue-Shan Lin, Ko-Hung Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fertil Steril (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fertnstert.2005.03.075"}], "href": "https://doi.org/10.1016/j.fertnstert.2005.03.075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16209998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16209998"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Huei-Ting Yang, Mark Peggie, Philip Cohen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.01.166"}], "href": "https://doi.org/10.1016/j.bbrc.2009.01.166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19285026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19285026"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Richard W P Smith, Ross C Anderson, Joel W S Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.2717711"}], "href": "https://doi.org/10.1261/rna.2717711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21576381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21576381"}]}]}]}
Proteins	DAZP1_HUMAN
NCBI Gene ID	26528
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DAZAP1 has 7,224 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for DAZAP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DAZAP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DAZAP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DAZAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DAZAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DAZAP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DAZAP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DAZAP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DAZAP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DAZAP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DAZAP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DAZAP1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DAZAP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DAZAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DAZAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DAZAP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DAZAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DAZAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DAZAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DAZAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DAZAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DAZAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DAZAP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DAZAP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DAZAP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DAZAP1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DAZAP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DAZAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DAZAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DAZAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DAZAP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DAZAP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DAZAP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DAZAP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with DAZAP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with DAZAP1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DAZAP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DAZAP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing DAZAP1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of DAZAP1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of DAZAP1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of DAZAP1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.