{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The dysbindin domain‐containing protein 1 (DBNDD1) is an evolutionarily conserved gene product whose biological roles are emerging from diverse experimental settings. On the one hand, its genomic locus has been exploited as a target for precise gene‐modification strategies in rats, where knockin of reporter genes into the DBNDD1 region improved homologous recombination efficiency (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In human genetic studies, DBNDD1 has been prioritized as one of the most significantly associated genes with melanoma susceptibility in genome‐wide analyses, suggesting that alterations in its regulation or function may contribute to cutaneous oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n From a protein structure perspective, nuclear magnetic resonance investigations have revealed that human DBNDD1 is intrinsically disordered. This structural plasticity may be indicative of roles in protein–protein interactions or regulatory functions that require conformational flexibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, proteomic analyses in a Parkinson’s disease mouse model identified DBNDD1 among several dysregulated proteins, implicating it in endogenous stress responses and potential mitochondrial or synaptic dysregulations that underlie midbrain vulnerability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, the locus of DBNDD1 has been employed in studies of natural genetic variation, where its allelic variation contributed to resolving the complex genomic admixture in Japanese house mice, further underlining its conservation and utility as a genetic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight that although the precise cellular functions of DBNDD1 remain to be fully elucidated, its conserved intrinsically disordered structure, association with disease susceptibility, and differential regulation in stress models point to a multifaceted role in both normal physiology and pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuanwu Ma, Wei Chen, Xu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2016.1185591"}], "href": "https://doi.org/10.1080/15476286.2016.1185591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27163284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27163284"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shenying Fang, Jiachun Lu, Xinke Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional annotation of melanoma risk loci identifies novel susceptibility genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgz173"}], "href": "https://doi.org/10.1093/carcin/bgz173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31630191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31630191"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christoph Wiedemann, Kingsley Benjamin Obika, Sandra Liebscher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Backbone and side chain resonance assignment of the intrinsically disordered human DBNDD1 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomol NMR Assign (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12104-022-10086-3"}], "href": "https://doi.org/10.1007/s12104-022-10086-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35474152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35474152"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Georg Auburger, Suzana Gispert, Nadine Brehm "}, {"type": "b", "children": [{"type": "t", "text": "Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Parkinsons Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2016/4686185"}], "href": "https://doi.org/10.1155/2016/4686185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27034888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27034888"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mitsuo Nunome, Chikako Ishimori, Ken P Aplin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ecol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-294X.2010.04651.x"}], "href": "https://doi.org/10.1111/j.1365-294X.2010.04651.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20465587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20465587"}]}]}]}