DCAF11 Gene

HGNC Family	DDB1 and CUL4 associated factors (DCAF), WD repeat domain containing (WDR)
Name	DDB1 and CUL4 associated factor 11
Description	This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DCAF11 is emerging as an important substrate receptor within CUL4‐RING ubiquitin ligase complexes that governs the proteolytic turnover of key regulatory proteins in diverse cellular contexts. For example, electrophilic proteolysis‐targeting chimeras (PROTACs) covalently modify specific cysteine residues in DCAF11 to promote the ubiquitination and degradation of target proteins in human cells, highlighting its role in ligand‐induced protein elimination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In human osteosarcoma cells, DCAF11 partners with CUL4B, DDB1, and RBX1 to form an E3 ligase complex that likely contributes to the regulation of cell cycle-related factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, DCAF11 directly binds a phosphorylated fragment of stem‐loop binding protein (SLBP) to target it for degradation at the end of S phase, a process that is essential for proper histone mRNA maturation and cell viability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In renal cell carcinoma, DCAF11 is integrated within a competing endogenous RNA network where its expression is modulated by microRNA‐942 and associated long non-coding RNAs, suggesting a role in tumor cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " During early embryogenesis and in embryonic stem cells, Dcaf11 facilitates telomere elongation by promoting the degradation of inhibitory chromatin factors, thereby ensuring proper telomere sister-chromatid exchange and chromatin remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, DCAF11 has been shown to mediate the polyubiquitination and degradation of phosphorylated CENP-A, a histone H3 variant essential for centromere identity, preventing its ectopic localization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, network analyses in the context of autoimmune liver disease-associated hepatocellular carcinoma have highlighted DCAF11 as a nodal regulatory factor and a promising candidate for biomarker development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoyu Zhang, Lena M Luukkonen, Christie L Eissler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Chem Soc (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/jacs.1c00990"}], "href": "https://doi.org/10.1021/jacs.1c00990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33783207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33783207"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhi Chen, Kun Wang, Canglong Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRL4B"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "DCAF11"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-01344-9"}], "href": "https://doi.org/10.1038/s41598-017-01344-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28446751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28446751"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Umidahan Djakbarova, William F Marzluff, M Murat Köseoğlu "}, {"type": "b", "children": [{"type": "t", "text": "DDB1 and CUL4 associated factor 11 (DCAF11) mediates degradation of Stem-loop binding protein at the end of S phase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2016.1191708"}], "href": "https://doi.org/10.1080/15384101.2016.1191708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27254819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27254819"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yicheng Chen, Jinkui He, Changju Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA‑942."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7311"}], "href": "https://doi.org/10.3892/or.2019.7311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31545458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31545458"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rongrong Le, Yixin Huang, Yanping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2020.11.018"}], "href": "https://doi.org/10.1016/j.stem.2020.11.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33357405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33357405"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kehui Wang, Yuting Liu, Zhouliang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2021.109987"}], "href": "https://doi.org/10.1016/j.celrep.2021.109987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34758320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34758320"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Soumyadeep Mukherjee, Arpita Kar, Najma Khatun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Familiarity Breeds Strategy: In Silico Untangling of the Molecular Complexity on Course of Autoimmune Liver Disease-to-Hepatocellular Carcinoma Transition Predicts Novel Transcriptional Signatures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10081917"}], "href": "https://doi.org/10.3390/cells10081917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34440687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34440687"}]}]}]}
Synonyms	GL014, PRO2389, WDR23
Proteins	DCA11_HUMAN
NCBI Gene ID	80344
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DCAF11 has 5,773 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 108 datasets.

Click the + buttons to view associations for DCAF11 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DCAF11 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCAF11 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCAF11 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DCAF11 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DCAF11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DCAF11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCAF11 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DCAF11 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCAF11 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCAF11 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DCAF11 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DCAF11 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DCAF11 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DCAF11 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DCAF11 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCAF11 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DCAF11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DCAF11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DCAF11 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DCAF11 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DCAF11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DCAF11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DCAF11 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DCAF11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DCAF11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DCAF11 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DCAF11 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DCAF11 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DCAF11 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DCAF11 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DCAF11 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DCAF11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DCAF11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DCAF11 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCAF11 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DCAF11 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DCAF11 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DCAF11 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DCAF11 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing DCAF11 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of DCAF11 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.