DCC Gene

HGNC Family	Fibronectin type III domain containing, Immunoglobulin superfamily domain containing
Name	DCC netrin 1 receptor
Description	This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The netrin‐1 receptor DCC plays multifaceted roles in both neural development and disease. Functioning as a dependence receptor, DCC mediates axon guidance by binding netrin‐1 to regulate growth cone dynamics, neurite extension, and cytoskeletal remodeling. Through direct interactions with signaling molecules such as RhoA, TUBB3, and myosin‐X—and by engaging regulators of alternative splicing—DCC influences axon outgrowth, midline crossing, and the proper formation of major commissural tracts (for example, those involved in corpus callosum formation and lateralization)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, by coupling extracellular netrin‐1 cues to intracellular signaling cascades—including RhoA inhibition and the control of local translation—DCC regulates chemotactic axon turning and the assembly of dopamine circuits in the mature brain."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": " Moreover, the alternative splicing of DCC transcripts—with regulation by RNA‐binding proteins such as NOVA—further refines its activity during commissural neuron development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its developmental functions, DCC acts as a tumor suppressor by functioning as a dependence receptor that triggers apoptosis in the absence of ligand. Epigenetic silencing or mutation of DCC has been linked with enhanced tumor aggressiveness and metastasis in various cancers, while alterations in its promoter methylation can serve as a potential biomarker for disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "20"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, genetic variation at the DCC locus has been associated with clinical phenotypes such as congenital mirror movements, agenesis of the corpus callosum, and even chronic back pain, highlighting its importance in both central nervous system wiring and adult neural plasticity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "21", "end_ref": "23"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Myriam Srour, Jean-Baptiste Rivière, Jessica M T Pham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in DCC cause congenital mirror movements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1186463"}], "href": "https://doi.org/10.1126/science.1186463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20431009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20431009"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yi Xie, Yu-Qiang Ding, Yan Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1321"}], "href": "https://doi.org/10.1038/ncb1321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16244667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16244667"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Giasuddin Ahmed, Yohei Shinmyo, Kunimasa Ohta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Draxin inhibits axonal outgrowth through the netrin receptor DCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0943-11.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.0943-11.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21957262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21957262"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Simon W Moore, James P Correia, Karen Lai Wing Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.024133"}], "href": "https://doi.org/10.1242/dev.024133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18653556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18653556"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Robert P Kruger, Jeeyong Lee, Weiquan Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3794"}], "href": "https://doi.org/10.1038/ng.3794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28250454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28250454"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ling Lin, Ole Isacson "}, {"type": "b", "children": [{"type": "t", "text": "Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1634/stemcells.2006-0119"}], "href": "https://doi.org/10.1634/stemcells.2006-0119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16840550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16840550"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zhiyi Wei, Jing Yan, Qing Lu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.14264"}], "href": "https://doi.org/10.7554/eLife.14264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27223328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27223328"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Chao Qu, Trisha Dwyer, Qiangqiang Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct binding of TUBB3 with DCC couples netrin-1 signaling to intracellular microtubule dynamics in axon outgrowth and guidance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.122184"}], "href": "https://doi.org/10.1242/jcs.122184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23641072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23641072"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Colleen Manitt, Andrea Mimee, Conrad Eng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.03.005"}], "href": "https://doi.org/10.1016/j.celrep.2018.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29590626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29590626"}]}]}]}
Synonyms	CRCR1, HGPPS2, NTN1R1, CRC18, MRMV1, IGDCC1
Proteins	DCC_HUMAN
NCBI Gene ID	1630
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DCC has 6,054 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for DCC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DCC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCC gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCC gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DCC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DCC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DCC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DCC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCC gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DCC gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DCC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DCC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DCC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DCC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DCC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with DCC gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DCC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DCC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DCC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DCC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DCC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DCC gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DCC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DCC gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DCC gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DCC gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DCC gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving DCC gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving DCC gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with DCC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DCC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DCC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DCC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DCC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DCC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DCC gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DCC gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DCC from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.