DCDC2C Gene

Name	doublecortin domain containing 2C
Description	Predicted to be involved in intracellular signal transduction. Located in cytoplasm and sperm flagellum. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent multidisciplinary studies have begun to elucidate the diverse roles of DCDC2C, a paralog within the doublecortin (DCX) superfamily whose members are known for their microtubule‐binding domains. Evolutionary and sequence analyses of the DCX gene family have shown that these domains have undergone sub‐specialization, and while alterations in related genes are linked to neurological and visual disorders, DCDC2C is emerging as a candidate with functions extending into immunological and reproductive contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a porcine model, genome‐wide association studies identified variants near DCDC2C that are associated with increased susceptibility to Salmonella infection, suggesting a potential role in modulating immune responses such as neutrophil recruitment or intracellular bacterial killing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, transcriptomic analyses in stress models have highlighted DCDC2C among several novel genes that had not previously been evaluated for their role in the stress response, indicating that DCDC2C’s expression may be influenced by external stressors and warrant further functional interrogation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Finally, integrated genomics approaches in studies of the human sperm microtubulome have validated the expression of DCDC2C in the sperm flagellum, implying that it may play a crucial part in the assembly, organization, or dynamic regulation of flagellar microtubules, with potential implications for sperm motility and male fertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Orly Reiner, Frédéric M Coquelle, Bastian Peter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The evolving doublecortin (DCX) superfamily."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2164-7-188"}], "href": "https://doi.org/10.1186/1471-2164-7-188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16869982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16869982"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Corinne H Schut, Abdolvahab Farzan, Russell S Fraser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of single-nucleotide variants associated with susceptibility to Salmonella in pigs using a genome-wide association approach."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Vet Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12917-020-02344-0"}], "href": "https://doi.org/10.1186/s12917-020-02344-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32414370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32414370"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Adrian M Stankiewicz, Aneta Jaszczyk, Joanna Goscik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prog Neuropsychopharmacol Biol Psychiatry (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pnpbp.2022.110558"}], "href": "https://doi.org/10.1016/j.pnpbp.2022.110558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35405299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35405299"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fanny Jumeau, Frédéric Chalmel, Francisco-Jose Fernandez-Gomez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defining the human sperm microtubulome: an integrated genomics approach."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.116.143479"}], "href": "https://doi.org/10.1095/biolreprod.116.143479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28395323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28395323"}]}]}]}
Proteins	DCD2C_HUMAN
NCBI Gene ID	728597
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DCDC2C has 1,141 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 48 datasets.

Click the + buttons to view associations for DCDC2C from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DCDC2C Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DCDC2C gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCDC2C gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCDC2C gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DCDC2C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DCDC2C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of DCDC2C gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DCDC2C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DCDC2C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DCDC2C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	dbGAP Gene-Trait Associations	traits associated with DCDC2C gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DCDC2C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DCDC2C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DCDC2C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DCDC2C gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCDC2C gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DCDC2C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GAD Gene-Disease Associations	diseases associated with DCDC2C gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of DCDC2C gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of DCDC2C gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of DCDC2C gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of DCDC2C gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GO Cellular Component Annotations 2023	cellular components containing DCDC2C protein from the curated GO Cellular Component Annotations 2023 dataset.
	GO Cellular Component Annotations 2025	cellular components containing DCDC2C protein from the curated GO Cellular Component Annotations 2025 dataset.
	GTEx eQTL 2025	SNPs regulating expression of DCDC2C gene from the GTEx eQTL 2025 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of DCDC2C gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of DCDC2C gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GWAS Catalog SNP-Phenotype Associations	phenotypes associated with DCDC2C gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with DCDC2C gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	GWASdb SNP-Disease Associations	diseases associated with DCDC2C gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
	GWASdb SNP-Phenotype Associations	phenotypes associated with DCDC2C gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
	HPA Tissue Protein Expression Profiles	tissues with high or low expression of DCDC2C protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
	HuBMAP ASCT+B Annotations	cell types associated with DCDC2C gene from the HuBMAP ASCT+B dataset.
	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	cell types associated with DCDC2C gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
	IMPC Knockout Mouse Phenotypes	phenotypes of mice caused by DCDC2C gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of DCDC2C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of DCDC2C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of DCDC2C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of DCDC2C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	MGI Mouse Phenotype Associations 2023	phenotypes of transgenic mice caused by DCDC2C gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	drug perturbations changing expression of DCDC2C gene from the NIBR DRUG-seq U2OS MoA Box dataset.
	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of DCDC2C gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	gene perturbations changing expression of DCDC2C gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of DCDC2C gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of DCDC2C gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of DCDC2C gene from the RummaGEO Gene Perturbation Signatures dataset.
	Tabula Sapiens Gene-Cell Associations	cell types with high or low expression of DCDC2C gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of DCDC2C protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with DCDC2C protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.